Brain 5-HT2A receptor binding and its neural network related to behavioral inhibition system

Kazuho Kojima, Shigeki Hirano, Yasuyuki Kimura, Chie Seki, Yoko Ikoma, Keisuke Takahata, Takehito Ito, Keita Yokokawa, Hiroki Hashimoto, Kazunori Kawamura, Ming Rong Zhang, Hiroshi Ito, Makoto Higuchi, Satoshi Kuwabara, Tetsuya Suhara, Makiko Yamada

研究成果: ジャーナルへの寄稿学術論文査読

6 被引用数 (Scopus)

抄録

The tendency to avoid punishment, called behavioral inhibition system, is an essential aspect of motivational behavior. Behavioral inhibition system is related to negative affect, such as anxiety, depression and pain, but its neural basis has not yet been clarified. To clarify the association between individual variations in behavioral inhibition system and brain 5-HT2A receptor availability and specify which brain networks were involved in healthy male subjects, using [18F]altanserin positron emission tomography and resting-state functional magnetic resonance imaging. Behavioral inhibition system score negatively correlated with 5-HT2A receptor availability in anterior cingulate cortex. A statistical model indicated that the behavioral inhibition system score was associated with 5-HT2A receptor availability, which was mediated by the functional connectivity between anterior cingulate cortex and left middle frontal gyrus, both of which involved in the cognitive control of negative information processing. Individuals with high behavioral inhibition system displays low 5-HT2A receptor availability in anterior cingulate cortex and this cognitive control network links with prefrontal-cingulate integrity. These findings have implications for underlying the serotonergic basis of physiologies in aversion.

本文言語英語
ページ(範囲)1337-1348
ページ数12
ジャーナルBrain Imaging and Behavior
16
3
DOI
出版ステータス出版済み - 06-2022
外部発表はい

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング
  • 神経学
  • 認知神経科学
  • 臨床神経学
  • 細胞および分子神経科学
  • 精神医学および精神衛生
  • 行動神経科学

フィンガープリント

「Brain 5-HT2A receptor binding and its neural network related to behavioral inhibition system」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル