Butyrate enhances the production of nitric oxide in mouse vascular endothelial cells in response to gamma interferon

Akiko Morikawa, Tsuyoshi Sugiyama, Naoki Koide, Isamu Mori, Mya Mya Mu, Tomoaki Yoshida, Ferdaus Hassan, Shamima Islam, Takashi Yokochi

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The effect of butyrate, a natural bacterial product of colonic bacterial flora, on nitric oxide (NO) production in murine vascular endothelial cell line END-D in response to IFN-γ and/or LPS was studied. Butyrate significantly augmented NO production in END-D cells in response to IFN-γ or IFN-γ + LPS, but not LPS alone. The NO production was augmented by the addition of butyrate until 6 h after the stimulation with IFN-γ or IFN-γ + LPS. The augmentation was abolished by the removal of butyrate from the cultures. Butyrate enhanced the expression of inducible type NO synthase (iNOS) in the stimulated END-D cells. Furthermore, butyrate-enhanced NO production in the presence of various signal inhibitors down-regulating the signal pathways using nuclear factor (NF)-κB, mitogen-activated protein (MAP) kinases and Janus tyrosine kinase. The putative mechanism of butyrate-induced augmentation of NO production in response to IFN-γ or IFN-γ + LPS is discussed.

本文言語English
ページ(範囲)33-38
ページ数6
ジャーナルJournal of Endotoxin Research
10
1
DOI
出版ステータスPublished - 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 微生物学
  • 免疫学
  • 分子生物学
  • 細胞生物学
  • 感染症

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