Calcineurin regulates cyclin D1 stability through dephosphorylation at T286

Takahiro Goshima, Makoto Habara, Keisuke Maeda, Shunsuke Hanaki, Yoichi Kato, Midori Shimada

研究成果: Article査読

抄録

The Calcineurin/NFAT (nuclear factor of activated T cells) pathway plays an essential role in the tumorigenic and metastatic properties in breast cancer. The molecular mechanism of the antiproliferative effect of calcineurin inhibition, however, is poorly understood. We found that calcineurin inhibition delayed cell cycle progression at G1/S, and promoted cyclin D1 degradation by inhibiting dephosphorylation at T286. Importantly, overexpression of cyclin D1 partially rescued delayed G1/S progression, thereby revealing cyclin D1 as a key factor downstream of calcineurin inhibition. Cyclin D1 upregulation is observed in human invasive breast cancers, and our findings indicate that dysregulation of T286 phosphorylation could play a role in this phenomenon. We therefore propose that targeting site specific phosphorylation of cyclin D1 could be a potential strategy for clinical intervention of invasive breast cancer.

本文言語English
論文番号12779
ジャーナルScientific reports
9
1
DOI
出版ステータスPublished - 01-12-2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • General

フィンガープリント 「Calcineurin regulates cyclin D1 stability through dephosphorylation at T286」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル