TY - JOUR
T1 - Calcium channels regulate neuronal function, gene expression, and development
AU - Nakao, Akito
AU - Takada, Yoshinori
AU - Mori, Yasuo
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Calcium ions (Ca2+) play important roles as secondary messengers in the body. The intracellular Ca2+ concentration is increased via 2 mechanisms: (1) is an influx of external Ca2+ and (2) Ca 2+ release from the endoplasmic reticulum. Ca2+ influx across the plasma membrane involves 3 main types of channels: voltage-dependent calcium channels (VDCCs), ligand-gated calcium channels, and transient receptor potential (TRP) channels. VDCCs are activated by depolarization of membrane potential. VDDC-mediated Ca2+ signaling is essential for neurotransmitter release, synaptic plasticity, and gene transcription. The TRP family comprises at least 28 cation channels, most of which are permeable to Ca2+. TRP channels function as cellular sensors and are activated by various chemical and physical stimuli. In the nervous system, Ca2+ signaling via TRP channels is important for neuronal growth, development, survival, and cell death. In this review, we discuss how Ca2+ signaling via VDCCs and TRP channels mediates various neuronal processes.
AB - Calcium ions (Ca2+) play important roles as secondary messengers in the body. The intracellular Ca2+ concentration is increased via 2 mechanisms: (1) is an influx of external Ca2+ and (2) Ca 2+ release from the endoplasmic reticulum. Ca2+ influx across the plasma membrane involves 3 main types of channels: voltage-dependent calcium channels (VDCCs), ligand-gated calcium channels, and transient receptor potential (TRP) channels. VDCCs are activated by depolarization of membrane potential. VDDC-mediated Ca2+ signaling is essential for neurotransmitter release, synaptic plasticity, and gene transcription. The TRP family comprises at least 28 cation channels, most of which are permeable to Ca2+. TRP channels function as cellular sensors and are activated by various chemical and physical stimuli. In the nervous system, Ca2+ signaling via TRP channels is important for neuronal growth, development, survival, and cell death. In this review, we discuss how Ca2+ signaling via VDCCs and TRP channels mediates various neuronal processes.
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M3 - Review article
C2 - 21747135
AN - SCOPUS:79960712382
SN - 1881-6096
VL - 63
SP - 657
EP - 667
JO - Brain and Nerve
JF - Brain and Nerve
IS - 7
ER -