Calcium-dependent GABA release from brain slices of morphinized mice

T. Nabeshima, C. M. Reese, I. K. Ho

研究成果: Article

3 引用 (Scopus)

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Acute morphine administration had no effect on the spontaneous release of (3H)-GABA and the Ca2+-dependent release from mouse striatum and cerebellum. No effect on (3H)-GABA release also was detected in the morphine tolerant and the 24 hours morphine abrupt withdrawal animals. However, Ca2+-dependent (3H)-GABA release from striatal slices was significantly increased in the morphine 72 hr abrupt withdrawal mice. The increase of the release was dependent on Ca2+ concentration in the medium. Naloxone enhanced (3H)-GABA release from striatum in morphine tolerant mice. However, (3H)-GABA release from cerebellum did not change by any morphine treatment. These results suggest that striatal GABAergic neurons participate in morphine withdrawal.

元の言語English
ページ(範囲)11-20
ページ数10
ジャーナルResearch Communications in Substances of Abuse
3
発行部数1
出版物ステータスPublished - 01-01-1982
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

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