Candidate genes or compounds for therapeutic tools against methamphetamine and/or morphine-induced dependence

Atsumi Nitta, Yu Ichiro Yamada, Akira Nakajima, Yukihiro Noda, Kiyofumi Yamada, Toshitaka Nabeshima

研究成果: Article査読

抄録

Drug dependence is one of most severe problems in all over the world, however, the mechanisms and related-genes have not been completely revealed. Here we would like to introduce tumor necrosis factor-α (TNF-α). Repeated treatment with methamphetamine induced an increase in TNF-α mRNA in the some brain regions. Exogenous TNF-α blocked the methamphetamine rewarding. TNF-α plays a neuroprotective role in methamphetamine drug dependence. These results suggest that TNF-α is one of key proteins. TNF-α itself might not be therapeutic tools, since it has immunological actions in physical conditions. Therefore, next, we found a stimulator, Leu-Ile, which enhances TNF-α synthesis in cultured neurons. Leu-Ile protected blocked the methamphetamine-induced rewarding effects. These results suggest that a stimulator of TNF-α synthesis may be one of therapeutic tools against drug dependence.

本文言語English
ページ(範囲)81P-83P
ジャーナルFolia Pharmacologica Japonica
122
SUPPL. 1
出版ステータスPublished - 2003

All Science Journal Classification (ASJC) codes

  • Pharmacology

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