Carbapenems versus alternative antibiotics for the treatment of bloodstream infections caused by Enterobacter, Citrobacter or Serratia species: A systematic review with meta-analysis

Patrick N.A. Harris, Jane Y. Wei, Andrew W. Shen, Ahmed A. Abdile, Stuart Paynter, Rachel R. Huxley, Nirmala Pandeya, Yohei Doi, Kyungmin Huh, Catherine S. O'Neal, Thomas R. Talbot, David L. Paterson

研究成果: Article査読

32 被引用数 (Scopus)

抄録

Objectives: This systematic review and meta-analysis compared effects of different antibiotics on mortality in patients with bloodstream infections caused by Enterobacteriaceae with chromosomal AmpC β-lactamase. Methods: Databases were systematically searched for studies reporting mortality in patients with bloodstream infections caused by AmpC producers treated with carbapenems, broad-spectrum β-lactam/β-lactamase inhibitors (BLBLIs), quinolones or cefepime. Pooled ORs for mortality were calculated for cases that received monotherapy with these agents versus carbapenems. Registration: PROSPERO international prospective register of systematic reviews (CRD42014014992; 18 November 2014). Results: Eleven observational studies were included. Random-effects meta-analysis was performed on studies reporting empirical and definitive monotherapy. In unadjusted analyses, no significant difference in mortality was found between BLBLIs versus carbapenems used for definitive therapy (OR 0.87, 95% CI 0.32-2.36) or empirical therapy (OR 0.48; 95% CI 0.14-1.60) or cefepime versus carbapenems as definitive therapy (OR 0.61; 95% CI 0.27-1.38) or empirical therapy (0.60; 95% CI 0.17-2.20). Use of a fluoroquinolone as definitive therapy was associated with a lower risk of mortality compared with carbapenems (OR 0.39; 95% CI 0.19-0.78). Three studies with patient-level data were used to adjust for potential confounders. The non-significant trends favouring non-carbapenem options in these studies were diminished after adjustment for age, sex and illness severity scores, suggestive of residual confounding. Conclusions: Despite limitations of available data, there was no strong evidence to suggest that BLBLIs, quinolones or cefepime were inferior to carbapenems. The reduced risk of mortality observed with quinolone use may reflect less serious illness in patients, rather than superiority over carbapenems.

本文言語English
ページ(範囲)296-306
ページ数11
ジャーナルJournal of Antimicrobial Chemotherapy
71
2
DOI
出版ステータスPublished - 01-02-2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 微生物学(医療)
  • 感染症
  • 薬理学(医学)

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