Carbohydrate mimetic peptides as research reagent and therapeutic

Michiko N. Fukuda, Shingo Hatakeyama, Kazuhiro Sugihara

研究成果: Review article査読

5 被引用数 (Scopus)

抄録

Although numerous carbohydrates play significant roles in mammalian cells, development of carbohydrate-based reagents and therapeutics are hampered by the technical difficulty of chemically synthesizing complex carbohydrate structures. Use of carbohydrate mimetic peptides circumvents this difficulty, as short peptide can be easily synthesized and modified. We as well as others identified carbohydrate mimetic peptides by screening peptide displaying phage library using anti-carbohydrate antibodies and lectins. This review introduces our experiences with I-peptide that was used for identification of new carbohydrate binding receptor expressed in the lung endothelial cells, and those with IF7 peptide that can be used as a therapeutic against malignant tumors.

本文言語English
ページ(範囲)1626-1632
ページ数7
ジャーナルBiological and Pharmaceutical Bulletin
35
10
DOI
出版ステータスPublished - 10-2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

フィンガープリント

「Carbohydrate mimetic peptides as research reagent and therapeutic」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル