Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy: A cardiac biopsy study

Shin Ichiro Morimoto, Morie Sekiguchi, Akihisa Uemura, Shinya Hiramitsu, Katsutomo Kimura, Masatsugu Ohtsuki, Junichi Ishii, Shigeru Kato, Hiroshi Kasanuki, Hitoshi Hishida

研究成果: Article

3 引用 (Scopus)

抄録

Apical hypertrophic cardiomyopathy has been divided into two entities: apical asymmetric septal hypertrophy (apical ASH) and apical symmetric hypertrophy (AH). The latter differs clinically from hypertrophic cardiomyopathy (HCM) with ASH, and it is unclear whether AH represents a distinct subtype of HCM. In the present study, the presence or absence and the extent of cardiac muscle cell disorganization, a histologic characteristic of HCM, were compared in patients with AH (n = 10) and ASH (n = 29) in whom cardiac biopsy specimens were obtained from the left ventricular apex and interventricular septum. Disorganization was graded as (1+) in only 1 patient in the AH group and (-) in the remaining 9. In contrast, in the ASH group disorganization was graded as (1+) in 15 patients, (2+) in 7, (3+) in 3, and (-) in only 4 (P < 0.0001). Thus, it was observed that in AH disorganization is virtually absent or at most limited to a very narrow area. It is concluded from a histological stand point as well that the type of apical hypertrophic cardiomyopathy showing apical symmetric hypertrophy differs from usual HCM.

元の言語English
ページ(範囲)505-513
ページ数9
ジャーナルJapanese Heart Journal
44
発行部数4
DOI
出版物ステータスPublished - 01-12-2003

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Hypertrophic Cardiomyopathy
Cardiac Myocytes
Hypertrophy
Biopsy

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

これを引用

Morimoto, S. I., Sekiguchi, M., Uemura, A., Hiramitsu, S., Kimura, K., Ohtsuki, M., ... Hishida, H. (2003). Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy: A cardiac biopsy study. Japanese Heart Journal, 44(4), 505-513. https://doi.org/10.1536/jhj.44.505
Morimoto, Shin Ichiro ; Sekiguchi, Morie ; Uemura, Akihisa ; Hiramitsu, Shinya ; Kimura, Katsutomo ; Ohtsuki, Masatsugu ; Ishii, Junichi ; Kato, Shigeru ; Kasanuki, Hiroshi ; Hishida, Hitoshi. / Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy : A cardiac biopsy study. :: Japanese Heart Journal. 2003 ; 巻 44, 番号 4. pp. 505-513.
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Morimoto, SI, Sekiguchi, M, Uemura, A, Hiramitsu, S, Kimura, K, Ohtsuki, M, Ishii, J, Kato, S, Kasanuki, H & Hishida, H 2003, 'Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy: A cardiac biopsy study', Japanese Heart Journal, 巻. 44, 番号 4, pp. 505-513. https://doi.org/10.1536/jhj.44.505

Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy : A cardiac biopsy study. / Morimoto, Shin Ichiro; Sekiguchi, Morie; Uemura, Akihisa; Hiramitsu, Shinya; Kimura, Katsutomo; Ohtsuki, Masatsugu; Ishii, Junichi; Kato, Shigeru; Kasanuki, Hiroshi; Hishida, Hitoshi.

:: Japanese Heart Journal, 巻 44, 番号 4, 01.12.2003, p. 505-513.

研究成果: Article

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AU - Kimura, Katsutomo

AU - Ohtsuki, Masatsugu

AU - Ishii, Junichi

AU - Kato, Shigeru

AU - Kasanuki, Hiroshi

AU - Hishida, Hitoshi

PY - 2003/12/1

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N2 - Apical hypertrophic cardiomyopathy has been divided into two entities: apical asymmetric septal hypertrophy (apical ASH) and apical symmetric hypertrophy (AH). The latter differs clinically from hypertrophic cardiomyopathy (HCM) with ASH, and it is unclear whether AH represents a distinct subtype of HCM. In the present study, the presence or absence and the extent of cardiac muscle cell disorganization, a histologic characteristic of HCM, were compared in patients with AH (n = 10) and ASH (n = 29) in whom cardiac biopsy specimens were obtained from the left ventricular apex and interventricular septum. Disorganization was graded as (1+) in only 1 patient in the AH group and (-) in the remaining 9. In contrast, in the ASH group disorganization was graded as (1+) in 15 patients, (2+) in 7, (3+) in 3, and (-) in only 4 (P < 0.0001). Thus, it was observed that in AH disorganization is virtually absent or at most limited to a very narrow area. It is concluded from a histological stand point as well that the type of apical hypertrophic cardiomyopathy showing apical symmetric hypertrophy differs from usual HCM.

AB - Apical hypertrophic cardiomyopathy has been divided into two entities: apical asymmetric septal hypertrophy (apical ASH) and apical symmetric hypertrophy (AH). The latter differs clinically from hypertrophic cardiomyopathy (HCM) with ASH, and it is unclear whether AH represents a distinct subtype of HCM. In the present study, the presence or absence and the extent of cardiac muscle cell disorganization, a histologic characteristic of HCM, were compared in patients with AH (n = 10) and ASH (n = 29) in whom cardiac biopsy specimens were obtained from the left ventricular apex and interventricular septum. Disorganization was graded as (1+) in only 1 patient in the AH group and (-) in the remaining 9. In contrast, in the ASH group disorganization was graded as (1+) in 15 patients, (2+) in 7, (3+) in 3, and (-) in only 4 (P < 0.0001). Thus, it was observed that in AH disorganization is virtually absent or at most limited to a very narrow area. It is concluded from a histological stand point as well that the type of apical hypertrophic cardiomyopathy showing apical symmetric hypertrophy differs from usual HCM.

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Morimoto SI, Sekiguchi M, Uemura A, Hiramitsu S, Kimura K, Ohtsuki M その他. Cardiac muscle cell disorganization in apical hypertrophic cardiomyopathy: A cardiac biopsy study. Japanese Heart Journal. 2003 12 1;44(4):505-513. https://doi.org/10.1536/jhj.44.505