Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population

Elitza T. Betcheva, Taisei Mushiroda, Atsushi Takahashi, Michiaki Kubo, Sena K. Karachanak, Irina T. Zaharieva, Radoslava V. Vazharova, Ivanka I. Dimova, Vihra K. Milanova, Todor Tolev, George Kirov, Michael J. Owen, Michael C. O'Donovan, Naoyuki Kamatani, Yusuke Nakamura, Draga I. Toncheva

研究成果: Article

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The development of molecular psychiatry in the last few decades identified a number of candidate genes that could be associated with schizophrenia. A great number of studies often result with controversial and non-conclusive outputs. However, it was determined that each of the implicated candidates would independently have a minor effect on the susceptibility to that disease. Herein we report results from our replication study for association using 255 Bulgarian patients with schizophrenia and schizoaffective disorder and 556 Bulgarian healthy controls. We have selected from the literatures 202 single nucleotide polymorphisms (SNPs) in 59 candidate genes, which previously were implicated in disease susceptibility, and we have genotyped them. Of the 183 SNPs successfully genotyped, only 1 SNP, rs6277 (C957T) in the DRD2 gene (P=0.0010, odds ratio=1.76), was considered to be significantly associated with schizophrenia after the replication study using independent sample sets. Our findings support one of the most widely considered hypotheses for schizophrenia etiology, the dopaminergic hypothesis.

元の言語English
ページ(範囲)98-107
ページ数10
ジャーナルJournal of Human Genetics
54
発行部数2
DOI
出版物ステータスPublished - 02-2009

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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    Betcheva, E. T., Mushiroda, T., Takahashi, A., Kubo, M., Karachanak, S. K., Zaharieva, I. T., Vazharova, R. V., Dimova, I. I., Milanova, V. K., Tolev, T., Kirov, G., Owen, M. J., O'Donovan, M. C., Kamatani, N., Nakamura, Y., & Toncheva, D. I. (2009). Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. Journal of Human Genetics, 54(2), 98-107. https://doi.org/10.1038/jhg.2008.14