CD109: a multifunctional GPI-anchored protein with key roles in tumor progression and physiological homeostasis

Shinji Mii, Atsushi Enomoto, Yukihiro Shiraki, Tetsuro Taki, Yoshiki Murakumo, Masahide Takahashi

研究成果: Review article査読

15 被引用数 (Scopus)

抄録

CD109 is a glycosylphosphatidylinositol-anchored glycoprotein and a member of the α2-macroglobulin/C3,C4,C5 family of thioester-containing proteins first identified as being expressed on blood cells, including activated T cells and platelets, and a subset of CD34 + bone marrow cells containing megakaryocyte progenitors. Although CD109 carries the biallelic platelet-specific alloantigen Gov, the physiological functions or roles of CD109 in human disease remain largely unknown. It was recently demonstrated that CD109 is expressed in many malignant tumors, including various squamous cell carcinomas and adenocarcinomas, and plays a role as a multifunctional coreceptor. CD109 reportedly associates with transforming growth factor (TGF)-β receptors and negatively regulates TGF-β signaling in keratinocytes. Additionally, CD109 is potentially related to signal transducer and activator of transcription-3 signaling and aberrant cell proliferation. In this review, we describe recent evidence of CD109-specific significance in malignant tumors shown in mouse models and human tissues. Furthermore, we discuss the physiological functions of CD109 in vitro and in vivo, including results of phenotype analyses of CD109-deficient mice exhibiting epidermal hyperplasia and osteopenia.

本文言語English
ページ(範囲)249-259
ページ数11
ジャーナルPathology International
69
5
DOI
出版ステータスPublished - 05-2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • 病理学および法医学

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