CD22 serves as a receptor for soluble IgM

Takahiro Adachi, Satoru Harumiya, Hiromu Takematsu, Yasunori Kozutsumi, Matthias Wabl, Manabu Fujimoto, Thomas F. Tedder

研究成果: Article査読

28 被引用数 (Scopus)

抄録

CD22 (Siglec-2) is a B-cell membrane-bound lectin that recognizes glycan ligands containing α2,6-linked sialic acid (α2,6Sia) and negatively regulates signaling through the B-cell Ag receptor (BCR). Although CD22 has been investigated extensively, its precise function remains unclear due to acting multiple phases. Here, we demonstrate that CD22 is efficiently activated in trans by complexes of Ag and soluble IgM (sIgM) due to the presence of glycan ligands on sIgM. This result strongly suggests sIgM as a natural trans ligand for CD22. Also, CD22 appears to serve as a receptor for sIgM, which induces a negative feedback loop for B-cell activation similar to the Fc receptor for IgG (FcγRIIB).

本文言語English
ページ(範囲)241-247
ページ数7
ジャーナルEuropean Journal of Immunology
42
1
DOI
出版ステータスPublished - 01-2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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