CD9 gene variations are not associated with female infertility in humans

Sachie Nishiyama, Taro Kishi, Takema Kato, MacHiko Suzuki, Haruki Nishizawa, Kanako Pryor-Koishi, Tomio Sawada, Yukio Nishiyama, Nakao Iwata, Yasuhiro Udagawa, Hiroki Kurahashi

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Background/Aims: To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans. Methods: We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphisms (SNPs) in this gene using an additional 164 samples obtained from a fertile control group. Results: No disease-causing mutation in the CD9 gene was evident in these samples and no significant association between the tagging SNPs and the studied cohort was identified. Conclusions: Our findings do not support the hypothesis that genetic alterations of the CD9 gene cause female infertility in humans.

本文言語English
ページ(範囲)116-121
ページ数6
ジャーナルGynecologic and Obstetric Investigation
69
2
DOI
出版ステータスPublished - 03-2010

All Science Journal Classification (ASJC) codes

  • 生殖医学
  • 産婦人科学

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