Ceftibuten-containing agar plate for detecting group B streptococci with reduced penicillin susceptibility (PRGBS)

Chitose Kamiya, Kouji Kimura, Yo Doyama, Akira Miyazaki, Makiko Morimoto, Hirotsugu Banno, Noriyuki Nagano, Wanchun Jin, Jun ichi Wachino, Keiko Yamada, Yoshichika Arakawa

研究成果: ジャーナルへの寄稿学術論文査読

8 被引用数 (Scopus)

抄録

Penicillins remain first-line agents for treatment of group B Streptococcus (. Streptococcus agalactiae; GBS) infections; however, several reports have confirmed the existence of GBS with reduced penicillin susceptibility (PRGBS). Because no selective agar plates for detection of PRGBS are available to date, in this investigation, we developed the selective agar plate for detection of PRGBS. We used 19 genetically well-confirmed PRGBS isolates and 38 penicillin-susceptible GBS isolates identified in Japan. For preparation of trial PRGBS-selective agar plates, we added 1 of antimicrobial agents (among oxacillin, ceftizoxime, and ceftibuten) to a well-established GBS-selective agar plate. Among 12 trial PRGBS-selective agar plates, Muller-Hinton agar containing 128. μg/mL ceftibuten with 5% sheep blood, 8. μg/mL gentamicin, and 12. μg/mL nalidixic acid was the most appropriate selective agar for PRGBS, showing 100% sensitivity and 81.6% specificity. In cases of potential nosocomial spread of PRGBS, the selective agar plate could be useful and reliable.

本文言語英語
ページ(範囲)269-273
ページ数5
ジャーナルDiagnostic Microbiology and Infectious Disease
82
4
DOI
出版ステータス出版済み - 01-08-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 微生物学(医療)
  • 感染症

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