Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats

Ryoichi Banno; Hiroshi Arima; Masayuki Hayashi; Motomitsu Goto; Minemori Watanabe; Ikuko Sato; Nobuaki Ozaki; Hiroshi Nagasaki; Noriyuki Ozaki; Yutaka Oiso

doi:10.1016/j.febslet.2007.02.019

Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats

Ryoichi Banno, Hiroshi Arima, Masayuki Hayashi, Motomitsu Goto, Minemori Watanabe, Ikuko Sato, Nobuaki Ozaki, Hiroshi Nagasaki, Noriyuki Ozaki, Yutaka Oiso

研究成果: Article › 査読

25 被引用数 (Scopus)

抄録

In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.

本文言語	English
ページ（範囲）	1131-1136
ページ数	6
ジャーナル	FEBS Letters
巻	581
号	6
DOI	https://doi.org/10.1016/j.febslet.2007.02.019
出版ステータス	Published - 20-03-2007
外部発表	はい

All Science Journal Classification (ASJC) codes

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

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10.1016/j.febslet.2007.02.019

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abstract = "In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.",

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AU - Banno, Ryoichi

AU - Arima, Hiroshi

AU - Hayashi, Masayuki

AU - Goto, Motomitsu

AU - Watanabe, Minemori

AU - Sato, Ikuko

AU - Ozaki, Nobuaki

AU - Nagasaki, Hiroshi

AU - Ozaki, Noriyuki

AU - Oiso, Yutaka

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Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats

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