Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats

Ryoichi Banno, Hiroshi Arima, Masayuki Hayashi, Motomitsu Goto, Minemori Watanabe, Ikuko Sato, Nobuaki Ozaki, Hiroshi Nagasaki, Noriyuki Ozaki, Yutaka Oiso

研究成果: Article査読

24 被引用数 (Scopus)

抄録

In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.

本文言語English
ページ(範囲)1131-1136
ページ数6
ジャーナルFEBS Letters
581
6
DOI
出版ステータスPublished - 20-03-2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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