抄録
In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.
本文言語 | English |
---|---|
ページ(範囲) | 1131-1136 |
ページ数 | 6 |
ジャーナル | FEBS Letters |
巻 | 581 |
号 | 6 |
DOI | |
出版ステータス | Published - 20-03-2007 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 生物理学
- 構造生物学
- 生化学
- 分子生物学
- 遺伝学
- 細胞生物学