Cervical lymph nodes play the role of regional lymph nodes in brain tumour immunity in rats

Y. Okamoto, J. Yamashita, M. Hasegawa, H. Fujisawa, T. Yamashima, T. Hashimoto, A. Nonomura, Y. Matsumoto, S. Kida

研究成果: ジャーナルへの寄稿学術論文査読

16 被引用数 (Scopus)

抄録

Recent physiological and anatomical studies have demonstrated that a major fraction of brain interstitial and cerebrospinal fluid drains into cervical lymph nodes (CLN) in a number of experimental animals. To investigate the role of CLN in brain tumour immunity, temporal profiles of MHC class II molecule expression and T lymphocyte subsets in brain tumours. CLN and other lymphoid tissues were analysed by immunocytochemistry. A total of 64 Wistar rats weighing 250 g were used. Two weeks after the transplantation of C6 glioma cells (106 cells/l μl) into a rat brain, expression of MHC class II molecules was induced in the brain and all systemic lymphoid tissues examined. However, the subsequent appearance of CD4 or CD8 positive cells was strictly confined to CLN, and coincided with the infiltration of such cells into the brain tumour 2 weeks after transplantation. In the group of animals in which cervical lymphadenectomy was followed by intracerebral transplantation of C6 glioma cells, infiltration of CD4 or CD8 positive cells into the brain tumour was delayed until 3 weeks after the transplantation, and the production of such cells was by the spleen. These results suggest that CLN act as regional lymph nodes in brain tumour immunity.

本文言語英語
ページ(範囲)113-122
ページ数10
ジャーナルNeuropathology and Applied Neurobiology
25
2
DOI
出版ステータス出版済み - 1999

All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 組織学
  • 神経学
  • 臨床神経学
  • 生理学(医学)

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