Change of strategies and future perspectives against hepatitis B virus recurrence after liver transplantation

Masatoshi Ishigami, Yasuhiro Ogura, Yoshiki Hirooka, Hidemi Goto

研究成果: Review article査読

10 被引用数 (Scopus)

抄録

A few decades ago, liver transplantation in patients with chronic hepatitis B virus (HBV) infection was considered a relative contraindication because of the high rate of graft infections and poor prognosis. Since then, remarkable progress was introduced by using nucleos(t)ide analogues and/or hepatitis B immunoglobulin (HBIg) and liver transplantation for HBV-related disease is now becoming one of the good indication. However, high cost burden is the main problem for this combination prophylaxis for a long time use, and this issue should be emerged to be resolved. In this review, we show the progress of post anti-HBV strategies showing the history from introduction of HBIg and nucleos(t)ide analogues to recent new strategies with hepatitis B vaccine or saving or stopping protocols of HBIg, and clarify and discuss how to do for further improvement of prevention strategies with better quality.

本文言語English
ページ(範囲)10290-10298
ページ数9
ジャーナルWorld Journal of Gastroenterology
21
36
DOI
出版ステータスPublished - 28-09-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 消化器病学

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