TY - JOUR
T1 - Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein
AU - Yamada, Kiyofumi
AU - Nitta, Atsumi
AU - Saito, Tsuyoshi
AU - Hu, Jianguo
AU - Nabeshima, Toshitaka
N1 - Funding Information:
This study was supportedi,n part, by a grant (No. 007557009f)r om the Ministry of Education,S ciencea nd Culture of Japan, a grantf rom the Ministry of Health and Welfare Foundationfo r GerontologicaSl cienceR esearch (91A-2406), an SRF Grant for Biomedical Research,a grant from the Japan ResearchF oundationf or Clinical Pharmacologya, nd a grant from the Uehara Memorial Foundation.
PY - 1995/12/8
Y1 - 1995/12/8
N2 - We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.
AB - We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.
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U2 - 10.1016/0304-3940(95)12161-7
DO - 10.1016/0304-3940(95)12161-7
M3 - Article
C2 - 8848241
AN - SCOPUS:0028802698
SN - 0304-3940
VL - 201
SP - 155
EP - 158
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -