Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein

Kiyofumi Yamada, Atsumi Nitta, Tsuyoshi Saito, Jianguo Hu, Toshitaka Nabeshima

研究成果: ジャーナルへの寄稿学術論文査読

14 被引用数 (Scopus)

抄録

We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.

本文言語英語
ページ(範囲)155-158
ページ数4
ジャーナルNeuroscience Letters
201
2
DOI
出版ステータス出版済み - 08-12-1995
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学一般

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