Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of β-amyloid(1-40) protein

Kiyofumi Yamada, Atsumi Nitta, Tsuyoshi Saito, Jianguo Hu, Toshitaka Nabeshima

研究成果: Article

14 引用 (Scopus)

抜粋

We have previously shown that the continuous intracerebroventricular infusion of β-amyloid(1-40) protein results in memory impairments in rats, associated with a reduction of choline acetyltransferase activity in the frontal cortex and hippocampus. In the present study, we examined whether the infusion of β-amyloid(1-40) protein affected the content of ciliary neurotrophic factor (CNTF) in the rat brain. The β-amyloid(1-40) infusion increased CNTF content in the frontal cortex, hippocampus, and the cerebellum, but decreased its content in the brain stem. These results suggest that accumulation of β-amyloid(1-40) in the brain may affect CNTF production in vivo.

元の言語English
ページ(範囲)155-158
ページ数4
ジャーナルNeuroscience Letters
201
発行部数2
DOI
出版物ステータスPublished - 08-12-1995
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用