Changes in concentrations of dopamine, serotonin, and their metabolites induced by carbon monoxide (CO) in the rat striatum as determined by in vivo microdialysis

M. Hiramatsu, S. Yokoyama, T. Nabeshima, T. Kameyama

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Striatal microdialysis was performed in rats exposed to carbon monoxide (CO). Extracellular changes of dopamine, serotonin, and their metabolites were monitored before and after CO exposure at 15-min intervals by HPLC analysis. After CO exposure, extracellular dopamine increased (3.8 times that of baseline), whereas 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) decreased (by 20-25% of baseline). The decrease in HVA at individual time points, however, was not significant. After a transient increment of the dopamine, it was cleared from the extracellular fluid within 45 min and reached a stable level. Serotonin and 5-hydroxyindoleacetic acid (5-HIAA) showed a pattern different to that of dopamine and its acid metabolites, i.e., the changes in extracellular levels were small. Pretreatment with dizocilpine (MK-801), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, 45 min before CO exposure antagonized the changes in the extracellular concentration of DOPAC. However, the change in dopamine levels was not antagonized by pretreatment with MK-801. MK-801 itself had no effect on the levels of monoamines. Therefore, NMDA receptors may not have an important role for regulating striatal dopamine neurons in hypoxic condition.

本文言語English
ページ(範囲)9-15
ページ数7
ジャーナルPharmacology, Biochemistry and Behavior
48
1
DOI
出版ステータスPublished - 01-01-1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 毒物学
  • 薬理学
  • 臨床生化学
  • 生物学的精神医学
  • 行動神経科学

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