Changes in microsomal lysophospholipid acyltransferase activity are correlated with rat parotid gland enlargement induced by chronic administration of isoproterenol

Koji Yashiro, Yasunaga Kameyama, Masako Mizuno-kamiya, Sun Ok Shin, Akira Shinkai, Fuyuakira Takatsu, Yutaka Yokota

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Chronic (5- and 10-day) administration of isoproterenol, an agent that induces the proliferation of salivary gland cells, produced increases in microsomal 1-acyl-sn-glycero-3-phosphate acyltransferase and 1-acyl-sn-glycero-3-phosphocholine acyltransferase activity in rat parotid glands in parallel with gland enlargement. This increased activity was reduced when the treatment was stopped, the reduction corresponding to the reduction in gland weight. There were significant correlations between lysophospholipid acyltransferase activity and gland weight, and between the activities of the two types of lysophospholipid acyltransferase. However, isoproterenol treatment did not affect any of the steps of the subsequent phospholipid N-methylation. These results suggest that the cell proliferation induced by chronic administration of isoproterenol in the parotid gland is accompanied by reversible and selective increases in microsomal lysophospholipid acyltrans-ferases.

本文言語English
ページ(範囲)1040-1046
ページ数7
ジャーナルJournal of Biochemistry
115
6
DOI
出版ステータスPublished - 06-1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学

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