Changes of Contractile Properties of Extensor Digitorum Longus in Response to Creatine-Analogue Administration and/or Hindlimb Suspension in Rats

T. Wakatsuki, Y. Ohira, K. Nakamura, T. Asakura, H. Ohno, M. Yamamoto

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Changes of contractile properties of extensor digitorum longus in response to hindlimb suspension and/or altered high-energy phosphate contents were studied in rats. A reduction of high-energy phosphates, especially phosphocreatine, was seen in rats fed creatine analogue β-guanidinopropionic acid (β-GPA), but they were elevated after 10-d supplementation of creatine. The one-half relaxation time was increased by feeding β-GPA, but was normalized by creatine supply. The fatigue resistance of creatine-depleted muscle was significantly improved, but tended to decrease by suspension and creatine supply, although it was still better than that in the control diet group. It is indicated that the contractile properties of muscle are influenced by the high-energy phosphate content. It is also suggested that the endurance capacity may be influenced by the mitochondrial respiratory capacity, but not necessarily by the levels of high-energy phosphates.

本文言語English
ページ(範囲)979-989
ページ数11
ジャーナルJapanese Journal of Physiology
45
6
DOI
出版ステータスPublished - 1995
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生理学

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