Characteristic biological activities of lipopolysaccharides from Sinorhizobium and Mesorhizobium

Yasuyo Tsukushi, Nobuo Kido, Kazuhiko Saeki, Tsuyoshi Sugiyama, Naoki Koide, Isamu Mori, Tomoaki Yoshida, Takashi Yokochi

研究成果: ジャーナルへの寄稿学術論文査読

9 被引用数 (Scopus)

抄録

The biological actions of lipopolysaccharides (LPSs) from Sinorhizobium meliloti, Mesorhizobium loti and Escherichia coli were compared. In biological activities including lethality, production of tumor necrosis factor (TNF)-α and nitric oxide (NO), adjuvant action and Limulus activity, LPS from S. meliloti exhibited stronger actions than LPS from M. loti, but had a weaker action than LPS from E. coli. On the other hand, M. loti LPS showed a higher activity to activate human complement than S. meliloti LPS. Further, there was a significant difference in polymyxin B binding between S. meliloti LPS and M. loti LPS, suggesting a difference in the lipid A structure. LPSs from S. meliloti and M. loti seem to exhibit characteristic biological actions that may be dependent on the difference in the lipid A structure.

本文言語英語
ページ(範囲)25-31
ページ数7
ジャーナルJournal of Endotoxin Research
10
1
DOI
出版ステータス出版済み - 2004

All Science Journal Classification (ASJC) codes

  • 微生物学
  • 免疫学
  • 分子生物学
  • 細胞生物学
  • 感染症

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