TY - JOUR
T1 - Characteristics of muscarinic cholinergic, γ-aminobutyric acidA and phencyclidine receptors in spontaneously epileptic rats; in vitro quantitative autoradiographic analysis
AU - Murase, Kenshi
AU - Nabeshima, Toshitaka
AU - Kameyama, Tsutomu
AU - Sasa, Masashi
AU - Takaori, Shuji
AU - Ujihara, Hisamitsu
AU - Ishihara, Kumatoshi
AU - Yamada, Junzo
AU - Serikawa, Tadao
PY - 1991/9/30
Y1 - 1991/9/30
N2 - Characteristics of muscarinic cholinergic (mACh), γ-aminobutyric acidA (GABAA) and phencyclidine (PCP) receptors in the spontaneously epileptic rats (SER), which exhibit both absence-like seizures and tonic convulsion, were examined using in vitro quantitative autoradiography. Computer analysis using autoradiographic technique revealed that the amount of the specific binding of [3H]quinuclidinyl benzilate (QNB) to mACh receptors in the striatum of SER was more than that of zitter rats, not exhibiting both seizures and convulsion. However, the specific bindings of [3H]muscimol and [3H]N-(2-thienyl)cyclohexyl)3,4-piperidine (TCP) to GABAA and PCP receptors, respectively, of SER were not different from those of zitter rats in various regions tested. These results suggest that hyperfunction of mACh receptors in the striatum is involved in the appearance of absence-like seizures and tonic convulsion of SER.
AB - Characteristics of muscarinic cholinergic (mACh), γ-aminobutyric acidA (GABAA) and phencyclidine (PCP) receptors in the spontaneously epileptic rats (SER), which exhibit both absence-like seizures and tonic convulsion, were examined using in vitro quantitative autoradiography. Computer analysis using autoradiographic technique revealed that the amount of the specific binding of [3H]quinuclidinyl benzilate (QNB) to mACh receptors in the striatum of SER was more than that of zitter rats, not exhibiting both seizures and convulsion. However, the specific bindings of [3H]muscimol and [3H]N-(2-thienyl)cyclohexyl)3,4-piperidine (TCP) to GABAA and PCP receptors, respectively, of SER were not different from those of zitter rats in various regions tested. These results suggest that hyperfunction of mACh receptors in the striatum is involved in the appearance of absence-like seizures and tonic convulsion of SER.
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U2 - 10.1016/0304-3940(91)90323-L
DO - 10.1016/0304-3940(91)90323-L
M3 - Article
C2 - 1665211
AN - SCOPUS:0025999829
SN - 0304-3940
VL - 131
SP - 1
EP - 4
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -