Characteristics of muscarinic cholinergic, γ-aminobutyric acidA and phencyclidine receptors in spontaneously epileptic rats; in vitro quantitative autoradiographic analysis

Kenshi Murase, Toshitaka Nabeshima, Tsutomu Kameyama, Masashi Sasa, Shuji Takaori, Hisamitsu Ujihara, Kumatoshi Ishihara, Junzo Yamada, Tadao Serikawa

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Characteristics of muscarinic cholinergic (mACh), γ-aminobutyric acidA (GABAA) and phencyclidine (PCP) receptors in the spontaneously epileptic rats (SER), which exhibit both absence-like seizures and tonic convulsion, were examined using in vitro quantitative autoradiography. Computer analysis using autoradiographic technique revealed that the amount of the specific binding of [3H]quinuclidinyl benzilate (QNB) to mACh receptors in the striatum of SER was more than that of zitter rats, not exhibiting both seizures and convulsion. However, the specific bindings of [3H]muscimol and [3H]N-(2-thienyl)cyclohexyl)3,4-piperidine (TCP) to GABAA and PCP receptors, respectively, of SER were not different from those of zitter rats in various regions tested. These results suggest that hyperfunction of mACh receptors in the striatum is involved in the appearance of absence-like seizures and tonic convulsion of SER.

本文言語English
ページ(範囲)1-4
ページ数4
ジャーナルNeuroscience Letters
131
1
DOI
出版ステータスPublished - 30-09-1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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