Characterization of a multicomponent receptor for GDNF

J. J.S. Treanor, L. Goodman, F. De Sauvage, D. M. Stone, K. T. Poulsen, C. D. Beck, C. Gray, M. P. Armanini, R. A. Pollock, F. Hefti, H. S. Phillips, A. Goddard, M. W. Moore, A. Buj-Bello, A. M. Davies, N. Asai, M. Takahashi, R. Vandien, C. E. Henderson, A. Rosenthal

研究成果: Article査読

961 被引用数 (Scopus)

抄録

GLIAL-CELL-LINE-DERIVED neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Despite the potential clinical and physiological importance of GDNF, its mechanism of action is unknown. Here we show that physiological responses to GDNF require the presence of a novel glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR-α) that is expressed on GDNF-responsive ceils and binds GDNF with a high affinity. We further demonstrate that GDNF promotes the formation of a physical complex between GDNFR-α and the orphan tyrosine kinase receptor Ret, thereby inducing its tyrosine phosphorylation. These findings support the hypothesis that GDNF uses a multi-subunit receptor system in which GDNFR-α and Ret function as the ligand-binding and signalling components, respectively.

本文言語English
ページ(範囲)80-83
ページ数4
ジャーナルNature
382
6586
DOI
出版ステータスPublished - 02-08-1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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