抜粋
A chromosomally encoded class D β-lactamase, OXA-114, was characterized from Achromobacter xylosoxidans strain CIP69598. β-Lactamase OXA-114 shared 56% amino acid identity with the naturally occurring class D β-lactamase of Burkholderia cenocepacia and 42% identity with the acquired oxacillinases OXA-9 and OXA-18. OXA-114 has a narrow-spectrum hydrolysis profile, although it includes imipenem, at a very low level. PCR and sequencing revealed that blaOXA.114-like genes were identified in all A. xylosoxidans strains tested (n = 5), indicating that this β-lactamase is naturally occurring in that species. Induction experiments with imipenem and cefoxitin did not show inducibility of blaOXA.114 expression.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 1952-1956 |
| ページ数 | 5 |
| ジャーナル | Antimicrobial agents and chemotherapy |
| 巻 | 52 |
| 発行部数 | 6 |
| DOI | |
| 出版物ステータス | Published - 06-2008 |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
フィンガープリント Characterization of a naturally occurring class D β-lactamase from Achromobacter xylosoxidans' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Doi, Y., Poirel, L., Paterson, D. L., & Nordmann, P. (2008). Characterization of a naturally occurring class D β-lactamase from Achromobacter xylosoxidans. Antimicrobial agents and chemotherapy, 52(6), 1952-1956. https://doi.org/10.1128/AAC.01463-07