Characterization of a naturally occurring class D β-lactamase from Achromobacter xylosoxidans

Yohei Doi, Laurent Poirel, David L. Paterson, Patrice Nordmann

研究成果: Article査読

34 被引用数 (Scopus)

抄録

A chromosomally encoded class D β-lactamase, OXA-114, was characterized from Achromobacter xylosoxidans strain CIP69598. β-Lactamase OXA-114 shared 56% amino acid identity with the naturally occurring class D β-lactamase of Burkholderia cenocepacia and 42% identity with the acquired oxacillinases OXA-9 and OXA-18. OXA-114 has a narrow-spectrum hydrolysis profile, although it includes imipenem, at a very low level. PCR and sequencing revealed that blaOXA.114-like genes were identified in all A. xylosoxidans strains tested (n = 5), indicating that this β-lactamase is naturally occurring in that species. Induction experiments with imipenem and cefoxitin did not show inducibility of blaOXA.114 expression.

本文言語English
ページ(範囲)1952-1956
ページ数5
ジャーナルAntimicrobial agents and chemotherapy
52
6
DOI
出版ステータスPublished - 06-2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)
  • 感染症

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