The emergence of unusual DS-1-like intergenogroup reassortant rotaviruses with a bovinelike G8 genotype (DS-1-like G8P strains) has been reported in several Asian countries. During the rotavirus surveillance program in Japan in 2017, a DS-1-like G8P strain (RVA/Human-wt/JPN/ SO1162/2017/G8P) was identified in 43 rotavirus-positive stool samples. Strain SO1162 was shown to have a unique genotype constellation, including genes from both genogroup 1 and 2: G8-P-I2-R2- C2-M2-A2-N2-T2-E2-H2. Phylogenetic analysis revealed that the VP1 gene of strain SO1162 appeared to have originated from DS-1-like G1P strains from Thailand and Vietnam, while the remaining 10 genes were closely related to those of previously reported DS-1-like G8P strains. Thus, SO1162 was suggested to be a reassortant strain that acquired the VP1 gene from Southeast Asian DS-1-like G1P strains on the genetic background of co-circulating DS-1-like G8P strains. Our findings provide important insights into the evolutionary dynamics of emerging DS-1-like G8P strains.
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