抄録
ISP-1 is a naturally occurring immunosuppressant with a structure resembling that of sphingosine. ISP-1 inhibits serine palmitoyltransferase, the primary enzyme of sphingolipid biosynthesis and reduces intracellular sphingolipid, leading to cell death in mammalian cells and in yeast cells. To determine the mechanism underlying cell death induced by sphingolipid deprivation, ISP-1 resistant genes were isolated and characterized in yeast. Two genes were found to be tightly associated with sphingolipid signaling.
| 本文言語 | 英語 |
|---|---|
| ホスト出版物のタイトル | Sphingolipid Biology |
| 出版社 | Springer Japan |
| ページ | 463-474 |
| ページ数 | 12 |
| ISBN（印刷版） | 4431341986, 9784431341987 |
| DOI | |
| 出版ステータス | 出版済み - 2006 |
| 外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 生化学、遺伝学、分子生物学一般