Characterization of genes conferring resistance against ISP-1/myriocin-induced sphingolipid depletion in yeast

Hiromu Takematsu, Yasunori Kozutsumi

研究成果: Chapter

1 被引用数 (Scopus)

抄録

ISP-1 is a naturally occurring immunosuppressant with a structure resembling that of sphingosine. ISP-1 inhibits serine palmitoyltransferase, the primary enzyme of sphingolipid biosynthesis and reduces intracellular sphingolipid, leading to cell death in mammalian cells and in yeast cells. To determine the mechanism underlying cell death induced by sphingolipid deprivation, ISP-1 resistant genes were isolated and characterized in yeast. Two genes were found to be tightly associated with sphingolipid signaling.

本文言語English
ホスト出版物のタイトルSphingolipid Biology
出版社Springer Japan
ページ463-474
ページ数12
ISBN(印刷版)4431341986, 9784431341987
DOI
出版ステータスPublished - 2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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