TY - JOUR
T1 - Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS
AU - Iida, Ryuichi
AU - Yamada, Kiyofumi
AU - Mamiya, Takayoshi
AU - Saito, Kuniaki
AU - Seishima, Mitsuru
AU - Nabeshima, Toshitaka
N1 - Funding Information:
We thank Dr. Y. Sei for providing LP-BM5-MuLV. This study was supported in part by Grant-in-Aid #10780478 from the Ministry of Education, Science and Culture and Health Science Research Grant #H10-Special Research-026 from the Ministry of Health and Welfare to K. Saito, by Grants-in-Aid for Science Research from the Ministry of Education, Science, and Culture of Japan (No. 07557009, 08457027, 10897005 and 97450) to T. Nabeshima, and by a COE Grant.
PY - 1999/3/1
Y1 - 1999/3/1
N2 - Mice infected with an immunosuppressive murine leukemia virus mixture, LP-BM5 show a profound immunosuppression described as murine acquired immune deficiency syndrome (AIDS). In the present study, we characterized learning and memory deficits in C57BL/6 mice infected with LP-BMS. Spontaneous alternation behavior in a Y-maze and latent learning (spatial attention) in a water-finding test, as well as spatial reference and reversal learning in a water maze test, were significantly impaired in the mice infected with LP- BM5. These deficits appeared in the absence of any motoric and visual impairment as assessed by open-field, rotarod and visual water maze tests. These results suggest that cognitive functions are impaired in the mice infected with LP-BM5. Furthermore, LP-BM5-infected mice may be useful as a model for the AIDS dementia complex.
AB - Mice infected with an immunosuppressive murine leukemia virus mixture, LP-BM5 show a profound immunosuppression described as murine acquired immune deficiency syndrome (AIDS). In the present study, we characterized learning and memory deficits in C57BL/6 mice infected with LP-BMS. Spontaneous alternation behavior in a Y-maze and latent learning (spatial attention) in a water-finding test, as well as spatial reference and reversal learning in a water maze test, were significantly impaired in the mice infected with LP- BM5. These deficits appeared in the absence of any motoric and visual impairment as assessed by open-field, rotarod and visual water maze tests. These results suggest that cognitive functions are impaired in the mice infected with LP-BM5. Furthermore, LP-BM5-infected mice may be useful as a model for the AIDS dementia complex.
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U2 - 10.1016/S0165-5728(98)00259-8
DO - 10.1016/S0165-5728(98)00259-8
M3 - Article
C2 - 10229116
AN - SCOPUS:0033104069
SN - 0165-5728
VL - 95
SP - 65
EP - 72
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 1-2
ER -