Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS

Ryuichi Iida, Kiyofumi Yamada, Takayoshi Mamiya, Kuniaki Saito, Mitsuru Seishima, Toshitaka Nabeshima

研究成果: Article

17 引用 (Scopus)

抄録

Mice infected with an immunosuppressive murine leukemia virus mixture, LP-BM5 show a profound immunosuppression described as murine acquired immune deficiency syndrome (AIDS). In the present study, we characterized learning and memory deficits in C57BL/6 mice infected with LP-BMS. Spontaneous alternation behavior in a Y-maze and latent learning (spatial attention) in a water-finding test, as well as spatial reference and reversal learning in a water maze test, were significantly impaired in the mice infected with LP- BM5. These deficits appeared in the absence of any motoric and visual impairment as assessed by open-field, rotarod and visual water maze tests. These results suggest that cognitive functions are impaired in the mice infected with LP-BM5. Furthermore, LP-BM5-infected mice may be useful as a model for the AIDS dementia complex.

元の言語English
ページ(範囲)65-72
ページ数8
ジャーナルJournal of Neuroimmunology
95
発行部数1-2
DOI
出版物ステータスPublished - 01-03-1999
外部発表Yes

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Murine Acquired Immunodeficiency Syndrome
Memory Disorders
Inbred C57BL Mouse
Learning
Water
Maze Learning
Reversal Learning
AIDS Dementia Complex
Murine Leukemia Viruses
Vision Disorders
Immunosuppressive Agents
Visual Fields
Immunosuppression
Cognition

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

これを引用

Iida, Ryuichi ; Yamada, Kiyofumi ; Mamiya, Takayoshi ; Saito, Kuniaki ; Seishima, Mitsuru ; Nabeshima, Toshitaka. / Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS. :: Journal of Neuroimmunology. 1999 ; 巻 95, 番号 1-2. pp. 65-72.
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Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS. / Iida, Ryuichi; Yamada, Kiyofumi; Mamiya, Takayoshi; Saito, Kuniaki; Seishima, Mitsuru; Nabeshima, Toshitaka.

:: Journal of Neuroimmunology, 巻 95, 番号 1-2, 01.03.1999, p. 65-72.

研究成果: Article

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