Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

Mark A.G. Eldridge; Walter Lerchner; Richard C. Saunders; Hiroyuki Kaneko; Kristopher W. Krausz; Frank J. Gonzalez; Bin Ji; Makoto Higuchi; Takafumi Minamimoto; Barry J. Richmond

doi:10.1038/nn.4192

Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

Mark A.G. Eldridge
, Walter Lerchner
, Richard C. Saunders
, Hiroyuki Kaneko
, Kristopher W. Krausz
, Frank J. Gonzalez
, Bin Ji
, Makoto Higuchi
, Takafumi Minamimoto
, Barry J. Richmond

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

115 被引用数 (Scopus)

抄録

To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. These results suggest that retrieval of relative stimulus values from memory depends on the interaction between Rh and OFC.

本文言語	英語
ページ（範囲）	37-39
ページ数	3
ジャーナル	Nature Neuroscience
巻	19
号	1
DOI	https://doi.org/10.1038/nn.4192
出版ステータス	出版済み - 29-12-2015
外部発表	はい

All Science Journal Classification (ASJC) codes

神経科学一般

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10.1038/nn.4192

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abstract = "To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. These results suggest that retrieval of relative stimulus values from memory depends on the interaction between Rh and OFC.",

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AU - Kaneko, Hiroyuki

AU - Krausz, Kristopher W.

AU - Gonzalez, Frank J.

AU - Ji, Bin

AU - Higuchi, Makoto

AU - Minamimoto, Takafumi

AU - Richmond, Barry J.

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AB - To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. These results suggest that retrieval of relative stimulus values from memory depends on the interaction between Rh and OFC.

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Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

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