Children undergoing liver transplantation for treatment of inherited metabolic diseases are prone to higher oxidative stress, complement activity and transforming growth factor-β1

Mohamed Hamed Hussein, Takashi Hashimoto, Tatsuya Suzuki, Ghada Abdel Hamid Daoud, Tatenobu Goto, Yoko Nakajima, Takazumi Kato, Masahito Hibi, Hirokazu Tomishige, Fujio Hara, Shin Kato, Hiroki Kakita, Michi Kamei, Tetsuya Ito, Ineko Kato, Atsushi Sugioka, Hajime Togari

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Main indications for liver transplantation in the pediatric population include biliary atresia and inherited metabolic diseases. The present study evaluated whether there are differences between pediatric patients undergoing living-related liver transplantation due to the two diseases in terms of their oxidative and immunological status Pduring their regular outpatient follow-up visits. A clinical outpatient study measuring serum oxidative stress index (calculated as serum oxidant/antioxidant ratio, in the form of serum total hydroperoxide/serum biological antioxidative potential), serum terminal complement component 5a, as an indicator of complement activity and immunological status, and transforming growth factor-β1, as a marker of liver fibrosis, in 16 patients (6 males and 10 females, 2.5-15 years old) who received living-related liver transplantation due to inherited metabolic diseases (n=6; in the form of propionic acidemia [n=1], methylmalonic acidemia [n=1], arginase deficiency [n=1], tyrosinemia [n=2], and glycogen storage disease type 1b [n=1], with an age range of 2.4-14.6 years old) and due to biliary atresia ([n=10], with an age range of 2.9-14.5 years old). Serum oxidative stress index, complement component-5a, and transforming growth factor-β1 were significantly higher in the inherited metabolic diseases group than in the biliary atresia group. In all patients, serum oxidative stress index correlated positively with complement component-5a and transforming growth factor-β1. Patients who receive living-related liver transplantation due to inherited metabolic diseases are prone to higher oxidative stress, complement activity, and serum transforming growth factor-β1.

本文言語English
ページ(範囲)63-68
ページ数6
ジャーナルAnnals of Transplantation
18
1
DOI
出版ステータスPublished - 2013

All Science Journal Classification (ASJC) codes

  • 移植

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