Chlamydia pneumoniae infection enhances lectin-like oxidized low-density lipoprotein receptor (LOX-1) expression on human endothelial cells

Tomoaki Yoshida, Naoki Koide, Isamu Mori, Hiroyasu Ito, Takashi Yokochi

研究成果: ジャーナルへの寄稿学術論文査読

23 被引用数 (Scopus)

抄録

Many studies indicate that Chlamydia pneumoniae infection is a crucial risk factor in atherogenesis. The most relevant cell type for the pathogenesis is the macrophage, which possesses classical scavenger receptors that uptake oxidized low-density lipoprotein (LDL). Here, a direct involvement of vascular endothelial cells in atherogenesis was examined employing in vitro infection of human umbilical vein endothelial cells (HUVEC) with C. pneumoniae. Chlamydia pneumoniae infection greatly enhanced the uptake of oxidized LDL, but not of acetylated LDL, by HUVEC. Among the scavenger receptors analyzed, LOX-1 transcription, which prefers oxidized LDL to acetylated LDL, was significantly amplified.

本文言語英語
ページ(範囲)17-22
ページ数6
ジャーナルFEMS Microbiology Letters
260
1
DOI
出版ステータス出版済み - 07-2006

All Science Journal Classification (ASJC) codes

  • 微生物学
  • 分子生物学
  • 遺伝学

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