Chorangiosis and placental oxygenation

Kazunao Suzuki, Hiroaki Itoh, Satoshi Kimura, Kazuhiro Sugihara, Chizuko Yaguchi, Yukiko Kobayashi, Kyuya Hirai, Kinya Takeuchi, Motoi Sugimura, Naohiro Kanayama

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Chorangiosis is a vascular hyperplasia in the terminal chorionic villi, usually diagnosed histologically using the criteria of Altshuler. Its true etiology has not been fully identified, but chorangiosis has been proposed to result from a longstanding, rather low-grade hypoxia in the placental tissue. To clarify a possible association of placental oxygenation status with the development of chorangiosis, we measured placental tissue oxygen index (TOI) values using near-infrared spectroscopy (NIRS) before delivery and retrospectively compared them to the detection of placental chorangiosis, in a total of 47 (46 singleton and one set of dichorionic diamniotic twins) pregnant women. Small for gestational age (SGA) and/or maternal complications were observed in all cases of placental chorangiosis. Placental TOI values were significantly elevated in cases of chorangiosis. This indicates high oxygen saturation in the intervillous spaces because placental TOI values are expected to represent the oxygenation of maternal blood in the placental tissue. A possible preceding low efficiency of oxygen transfer to the fetal circulation in the villi might not only augment the oxygen saturation of maternal blood in intervillous spaces, but also cause rather low oxygenation in the capillaries of the villi and result in chorangiosis.

本文言語English
ページ(範囲)71-76
ページ数6
ジャーナルCongenital anomalies
49
2
DOI
出版ステータスPublished - 06-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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