Chordoma combined with Trousseau syndrome: a case report and literature review

Ruiying Rao, Ping Lin, Jinhe Xu, Chenxi Wang, Ying Chen, Shinji Ito, Tatsuro Mutoh, Zongyang Yu

研究成果: ジャーナルへの寄稿学術論文査読

抄録

Background: Trousseau syndrome (TS) refers to spontaneous, recurrent, and wandering arterial and venous thromboembolic events in patients with tumors. It results from abnormalities in coagulation and fibrinolytic mechanisms of varying degrees throughout the course of the disease. It has a high fatality rate, and it is commonly seen in patients with highly invasive tumors, such as lung, pancreatic, gastrointestinal, and breast cancers; however, to date, there has been no report of TS combined with chordoma. Case Description: A 56-year-old male with a diagnosis of chordoma underwent surgery, immunotherapy, immunotherapy combined with antiangiogenic therapy, chemotherapy combined with immunotherapy, and proton therapy for localized metastases. Subsequent to the worsening of chest tightness, a repeat chest computed tomography angiography (CTA) scan suggested pulmonary artery embolisms; eventually, a diagnosis of TS was made. After anticoagulation and synchronized antitumor therapy, the patient’s condition remained recurrent, eventually leading to death. Conclusions: TS is a frequent but easily overlooked clinical complication that can occur in a variety of tumors, including chordoma, and is currently diagnosed clinically. Thus, further exploration of its sensitive markers is needed. We have reported a case of chordoma combined with TS and conducted a literature review on TS to increase clinicians’ awareness of tumor-related thromboembolism and explore strategies to optimize the diagnosis, treatment, and prevention of TS.

本文言語英語
ページ(範囲)6249-6262
ページ数14
ジャーナルJournal of Thoracic Disease
16
9
DOI
出版ステータス出版済み - 30-09-2024

All Science Journal Classification (ASJC) codes

  • 呼吸器内科

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