TY - JOUR
T1 - Chromosome mapping of MHC class I in rainbow trout (Oncorhynchus mykiss)
AU - Fujiwara, Atushi
AU - Kiryu, Ikunari
AU - Dijkstra, Johannes Martinus
AU - Yoshiura, Yasutoshi
AU - Nishida-Umehara, Chizuko
AU - Ototake, Mitsuru
N1 - Funding Information:
This work was supported by research fellowships from the Japan Society for the Promotion of Science for Young Scientists, and by ‘the promotion of basic research activities for innovative biosciences’ funded by Bio-oriented Technology Research Advancement Institution (BRAIN), Japan. The clonal rainbow trout were kindly provided by the Nagano Prefectural Experimental Station of Fisheries, Nagano, Japan. We thank Dr James D. Moore, Bodega Marine Laboratory, U.S.A., for his help to edit this manuscript.
PY - 2003/2
Y1 - 2003/2
N2 - The major histocompatibility complex (MHC) is well-studied in mammals. Much research has addressed the genomic organisation of MHC genes and it is well established that human MHC class I genes are located on chromosome 6. However, information on the organisation of the MHC complex in rainbow trout is only beginning to become available. In the present study it was determined that rainbow trout MHC class I sequences are located on chromosome 18. This is the first reported use of fluorescence in situ hybridisation (FISH) to identify the chromosomal location of genes involved in the immune system of fish.
AB - The major histocompatibility complex (MHC) is well-studied in mammals. Much research has addressed the genomic organisation of MHC genes and it is well established that human MHC class I genes are located on chromosome 6. However, information on the organisation of the MHC complex in rainbow trout is only beginning to become available. In the present study it was determined that rainbow trout MHC class I sequences are located on chromosome 18. This is the first reported use of fluorescence in situ hybridisation (FISH) to identify the chromosomal location of genes involved in the immune system of fish.
UR - https://www.scopus.com/pages/publications/0037324342
UR - https://www.scopus.com/pages/publications/0037324342#tab=citedBy
U2 - 10.1006/fsim.2002.0426
DO - 10.1006/fsim.2002.0426
M3 - Article
C2 - 12526880
AN - SCOPUS:0037324342
SN - 1050-4648
VL - 14
SP - 171
EP - 175
JO - Fish and Shellfish Immunology
JF - Fish and Shellfish Immunology
IS - 2
ER -