Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice

Kuniaki Saito, Sanford P. Markey, Melvyn P. Heyes

研究成果: Article査読

68 被引用数 (Scopus)

抄録

Chronic infections are associated with increased concentrations of the neuroactive kynurenine pathway metabolite, quinolinic acid (QUIN), in blood and cerebrospinal fluid. In the present study, repeated injections of γ-interferon (5000 IU, every 3 days for 39 days) to C57BL6 mice were associated with persistent activation of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, in lung and brain, sustained increases in brain QUIN concentration and increases in plasma l-kynurenine and QUIN levels. Mice chronically treated with γ-interferon offer an animal model to investigate the effects of sustained immune stimulation on kynurenine pathway metabolism.

本文言語English
ページ(範囲)151-154
ページ数4
ジャーナルBrain Research
546
1
DOI
出版ステータスPublished - 12-04-1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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