TY - JOUR
T1 - Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice
AU - Saito, Kuniaki
AU - Markey, Sanford P.
AU - Heyes, Melvyn P.
PY - 1991/4/12
Y1 - 1991/4/12
N2 - Chronic infections are associated with increased concentrations of the neuroactive kynurenine pathway metabolite, quinolinic acid (QUIN), in blood and cerebrospinal fluid. In the present study, repeated injections of γ-interferon (5000 IU, every 3 days for 39 days) to C57BL6 mice were associated with persistent activation of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, in lung and brain, sustained increases in brain QUIN concentration and increases in plasma l-kynurenine and QUIN levels. Mice chronically treated with γ-interferon offer an animal model to investigate the effects of sustained immune stimulation on kynurenine pathway metabolism.
AB - Chronic infections are associated with increased concentrations of the neuroactive kynurenine pathway metabolite, quinolinic acid (QUIN), in blood and cerebrospinal fluid. In the present study, repeated injections of γ-interferon (5000 IU, every 3 days for 39 days) to C57BL6 mice were associated with persistent activation of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, in lung and brain, sustained increases in brain QUIN concentration and increases in plasma l-kynurenine and QUIN levels. Mice chronically treated with γ-interferon offer an animal model to investigate the effects of sustained immune stimulation on kynurenine pathway metabolism.
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U2 - 10.1016/0006-8993(91)91171-V
DO - 10.1016/0006-8993(91)91171-V
M3 - Article
C2 - 1830237
AN - SCOPUS:0025728920
SN - 0006-8993
VL - 546
SP - 151
EP - 154
JO - Brain Research
JF - Brain Research
IS - 1
ER -