Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice

Kuniaki Saito, Sanford P. Markey, Melvyn P. Heyes

研究成果: ジャーナルへの寄稿学術論文査読

75 被引用数 (Scopus)

抄録

Chronic infections are associated with increased concentrations of the neuroactive kynurenine pathway metabolite, quinolinic acid (QUIN), in blood and cerebrospinal fluid. In the present study, repeated injections of γ-interferon (5000 IU, every 3 days for 39 days) to C57BL6 mice were associated with persistent activation of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, in lung and brain, sustained increases in brain QUIN concentration and increases in plasma l-kynurenine and QUIN levels. Mice chronically treated with γ-interferon offer an animal model to investigate the effects of sustained immune stimulation on kynurenine pathway metabolism.

本文言語英語
ページ(範囲)151-154
ページ数4
ジャーナルBrain Research
546
1
DOI
出版ステータス出版済み - 12-04-1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学一般
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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