TY - JOUR
T1 - Cigarette smoking and serum soluble Fas levels
T2 - Findings from the JACC study
AU - Tamakoshi, Akiko
AU - Suzuki, Koji
AU - Lin, Yingsong
AU - Ito, Yoshinori
AU - Yagyu, Kiyoko
AU - Kikuchi, Shogo
AU - Watanabe, Yoshiyuki
AU - Inaba, Yutaka
AU - Tajima, Kazuo
AU - Nakachi, Kei
N1 - Funding Information:
Funds : The JACC Study has been supported by Grants-in-Aid for Scientific Research (Nos. 61010076 , 62010074 , 63010074 , 1010068 , 2151065 , 3151064 , 4151063 , 5151069 , 6279102 , 11181101 , 17015022 , 18014011 , 20014026 ) from MEXT, Japan.
Funding Information:
The authors express their sincere appreciation to Dr. Kunio Aoki, Professor Emeritus, Nagoya University School of Medicine and a former chairperson of the JACC Study, to Dr. Haruo Sugano, the former Director of the Cancer Institute, Tokyo, who greatly contributed to the initiation of the JACC Study, and to Dr. Yoshiyuki Ohno, Professor Emeritus, Nagoya University School of Medicine, who was also a former chairperson of the study. The authors also wish to thank Dr. Tomoyuki Kitagawa, of the Cancer Institute of the Japanese Foundation for Cancer Research and a former chairperson of a Grant-in-Aid for Scientific Research on Priority Area ‘Cancer’, for his valuable support of this study.
PY - 2009/9
Y1 - 2009/9
N2 - Cigarette smoking enhances low-grade systemic inflammation in the lung and other organs. Activated immune cells play an important role at early and late stages of inflammation, and in recent years, soluble Fas (sFas), an isoform of death molecule Fas, was found to interfere with the apoptotic pathways of these activated immune cells. The aim of this study was to confirm the association between cigarette smoking and sFas levels in healthy male subjects. We measured serum sFas levels of 4415 male subjects selected as controls for a nested case-control study within the large-scale cohort study conducted in Japan, called the JACC Study. Smoking status at baseline was evaluated by a self-administered questionnaire. Least square means of sFas according to smoking status and numbers of cigarettes smoked per day among smokers were calculated and adjusted for possible confounding factors. Mean sFas levels showed an increasing trend across never smokers, past smokers and current smokers, as 2.21 (95% CI: 2.14-2.27) ng/ml, 2.29 (2.22-2.36) ng/ml, and 2.36 (2.30-2.43) ng/ml, respectively. However, no dose-response relationship was observed between the number of cigarettes smoked per day and sFas levels among smokers.
AB - Cigarette smoking enhances low-grade systemic inflammation in the lung and other organs. Activated immune cells play an important role at early and late stages of inflammation, and in recent years, soluble Fas (sFas), an isoform of death molecule Fas, was found to interfere with the apoptotic pathways of these activated immune cells. The aim of this study was to confirm the association between cigarette smoking and sFas levels in healthy male subjects. We measured serum sFas levels of 4415 male subjects selected as controls for a nested case-control study within the large-scale cohort study conducted in Japan, called the JACC Study. Smoking status at baseline was evaluated by a self-administered questionnaire. Least square means of sFas according to smoking status and numbers of cigarettes smoked per day among smokers were calculated and adjusted for possible confounding factors. Mean sFas levels showed an increasing trend across never smokers, past smokers and current smokers, as 2.21 (95% CI: 2.14-2.27) ng/ml, 2.29 (2.22-2.36) ng/ml, and 2.36 (2.30-2.43) ng/ml, respectively. However, no dose-response relationship was observed between the number of cigarettes smoked per day and sFas levels among smokers.
UR - https://www.scopus.com/pages/publications/70249150708
UR - https://www.scopus.com/pages/publications/70249150708#tab=citedBy
U2 - 10.1016/j.mrgentox.2009.08.002
DO - 10.1016/j.mrgentox.2009.08.002
M3 - Article
C2 - 19682600
AN - SCOPUS:70249150708
SN - 1383-5718
VL - 679
SP - 79
EP - 83
JO - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
JF - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
IS - 1-2
ER -