Circadian Gene Circuitry Predicts Hyperactive Behavior in a Mood Disorder Mouse Model

Hideo Hagihara, Tomoyasu Horikawa, Hironori K. Nakamura, Juzoh Umemori, Hirotaka Shoji, Yukiyasu Kamitani, Tsuyoshi Miyakawa

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Bipolar disorder, also known as manic-depressive illness, causes swings in mood and activity levels at irregular intervals. Such changes are difficult to predict, and their molecular basis remains unknown. Here, we use infradian (longer than a day) cyclic activity levels in αCaMKII (Camk2a) mutant mice as a proxy for such mood-associated changes. We report that gene-expression patterns in the hippocampal dentate gyrus could retrospectively predict whether the mice were in a state of high or low locomotor activity (LA). Expression of a subset of circadian genes, as well as levels of cAMP and pCREB, possible upstream regulators of circadian genes, were correlated with LA states, suggesting that the intrinsic molecular circuitry changes concomitant with infradian oscillatory LA. Taken together, these findings shed light onto the molecular basis of how irregular biological rhythms and behavior are controlled by the brain.

本文言語English
ページ(範囲)2784-2796
ページ数13
ジャーナルCell Reports
14
12
DOI
出版ステータスPublished - 29-03-2016

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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