Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin

Takuro Arishima, Takashi Ito, Tomotsugu Yasuda, Nozomi Yashima, Hiroaki Furubeppu, Chinatsu Kamikokuryo, Takahiro Futatsuki, Yutaro Madokoro, Shotaro Miyamoto, Tomohiro Eguchi, Hiroyuki Haraura, Ikuro Maruyama, Yasuyuki Kakihana

研究成果: Article

3 引用 (Scopus)

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Background: Recombinant human soluble thrombomodulin (rTM) has been used for the treatment of disseminated intravascular coagulation in Japan, and an international phase III clinical trial for rTM is currently in progress. rTM mainly exerts its anticoagulant effects through an activated protein C (APC)-dependent mechanism, but the circulating APC levels after rTM treatment have not been clarified. This prospective observational study investigated plasma APC levels after rTM treatment. Methods: Plasma levels of soluble thrombomodulin, thrombin-antithrombin complex (TAT), protein C, and APC were measured in eight septic patients treated with rTM. APC generation in vitro was assessed in the presence or absence of rTM. Results: rTM significantly increased thrombin-mediated APC generation in vitro. In septic patients, soluble thrombomodulin levels were significantly increased during a 30-60-min period of rTM treatment and TAT levels were decreased. However, APC activity was not increased during the treatment period. Conclusions: Plasma APC activity is not increased in septic patients treated with rTM. It is possible that APC acts locally and does not circulate systemically.

元の言語English
記事番号24
ジャーナルThrombosis Journal
16
発行部数1
DOI
出版物ステータスPublished - 28-09-2018

All Science Journal Classification (ASJC) codes

  • Hematology

フィンガープリント Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Arishima, T., Ito, T., Yasuda, T., Yashima, N., Furubeppu, H., Kamikokuryo, C., Futatsuki, T., Madokoro, Y., Miyamoto, S., Eguchi, T., Haraura, H., Maruyama, I., & Kakihana, Y. (2018). Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin. Thrombosis Journal, 16(1), [24]. https://doi.org/10.1186/s12959-018-0178-0