Clinical and bacteriologic evaluation of OPC-7251 in patients with acne: A double-blind group comparison study versus cream base

Ichiro Kurokawa, Hirohiko Akamatsu, Setsuko Nishijima, Yasuo Asada, Shigekatsu Kawabata

研究成果: Article査読

48 被引用数 (Scopus)

抄録

Twenty-eight patients with acne were assigned to 4 weeks of treatment with OPC-7251 (a new fluoroquinolone derivative) 1% cream or the cream base in a double-blind manner to evaluate the antibacterial effect of the drug on resident bacteria in the hair follicles and to evaluate clinical response. Propionibacterium acnes was isolated from 21 of the 28 acne patients. When the number of P. acnes was compared before and after treatment, the posttreatment P. acnes count in the OPC-7251 1% cream group was significantly (p = 0.000) reduced compared with that in the cream base group. OPC-7251 1% cream was also significantly (p = 0.019) superior to the cream base in terms of clinical response. P. acnes and Staphylococcus epidermidis isolated from the acne lesions were selected for their susceptibility to various antibacterial agents. The minimal inhibitory concentration of OPC-7251 against P. acnes and S. epidermidis was 0.10 to 0.20 and 0.024 to 0.10 μg/ml, respectively, which indicates that the drug has a potent antibacterial effect.

本文言語English
ページ(範囲)674-681
ページ数8
ジャーナルJournal of the American Academy of Dermatology
25
4
DOI
出版ステータスPublished - 01-01-1991
外部発表はい

All Science Journal Classification (ASJC) codes

  • 皮膚病学

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