TY - JOUR
T1 - Clinical and histological features in pediatric and adolescent/young adult patients with renal disease
T2 - a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR)
AU - the Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology
AU - Urushihara, Maki
AU - Sato, Hiroshi
AU - Shimizu, Akira
AU - Sugiyama, Hitoshi
AU - Yokoyama, Hitoshi
AU - Hataya, Hiroshi
AU - Matsuoka, Kentaro
AU - Okamoto, Takayuki
AU - Ogino, Daisuke
AU - Miura, Kenichiro
AU - Hamada, Riku
AU - Hibino, Satoshi
AU - Shima, Yuko
AU - Yamamura, Tomohiko
AU - Kitamoto, Koichi
AU - Ishihara, Masayuki
AU - Konomoto, Takao
AU - Hattori, Motoshi
AU - Hasebe, Naoyuki
AU - Nakagawa, Naoki
AU - Shibazaki, Sekiya
AU - Miyamoto, Tomotsune
AU - Ito, Masanori
AU - Nishio, Saori
AU - Nakazawa, Daigo
AU - Sato, Yasuyuki
AU - Suzuki, Akira
AU - Moniwa, Norihito
AU - Tanaka, Marenao
AU - Fukasawa, Yuichiro
AU - Takizawa, Hideki
AU - Soma, Jun
AU - Nakaya, Izaya
AU - Kazama, Junichiro James
AU - Tanaka, Kennichi
AU - Tanaka, Mizuko
AU - Sato, Toshinobu
AU - Sanada, Satoru
AU - Hashimoto, Hideaki
AU - Miyazaki, Mariko
AU - Nagasawa, Tasuku
AU - Okamoto, Koji
AU - Konta, Tsuneo
AU - Ichikawa, Kazunobu
AU - Kitamura, Hiroshi
AU - Imasawa, Toshiyuki
AU - Yuzawa, Yukio
AU - Tsuboi, Naotake
AU - Hayashi, Hiroki
AU - Takahashi, Kazuo
N1 - Publisher Copyright:
© 2021, Japanese Society of Nephrology.
PY - 2021/9
Y1 - 2021/9
N2 - Background: Only a few studies have investigated epidemiological and clinicopathological information regarding pediatric and adolescent and young adult (AYA) patients with renal disease. The purpose of this study was to clarify the differences and relationship of clinicopathological findings between pediatric and AYA patients using the Japan Renal Biopsy Registry (J-RBR). Methods: This cross-sectional study analyzed data from patients registered in the J-RBR between 2007 and 2017. Clinicopathological findings at diagnosis were analyzed for 3,463 pediatric (age < 15 years) and 6,532 AYA (age 15–30 years) patients. Results: Although chronic nephritic syndrome was the most common clinical diagnosis at age > 5 years, nephrotic syndrome was the most frequent diagnosis at age < 4 years. The most common pathological diagnosis as classified by pathogenesis in pediatric patients was primary glomerular disease (except IgA nephropathy), whereas IgA nephropathy was increased in AYA patients. Mesangial proliferative glomerulonephritis was the most common pathological diagnosis as classified by histopathology in both pediatric and AYA patients. Minor glomerular abnormalities were the most frequent histopathologic diagnoses of nephrotic syndrome in childhood, but their frequency decreased with age. Conclusion: To the best of our knowledge, this is the first report of clinicopathological features of pediatric and AYA patients in a large nationwide registry of renal biopsy. There were differences of clinical, pathological and histopathologic findings between pediatric and AYA patients.
AB - Background: Only a few studies have investigated epidemiological and clinicopathological information regarding pediatric and adolescent and young adult (AYA) patients with renal disease. The purpose of this study was to clarify the differences and relationship of clinicopathological findings between pediatric and AYA patients using the Japan Renal Biopsy Registry (J-RBR). Methods: This cross-sectional study analyzed data from patients registered in the J-RBR between 2007 and 2017. Clinicopathological findings at diagnosis were analyzed for 3,463 pediatric (age < 15 years) and 6,532 AYA (age 15–30 years) patients. Results: Although chronic nephritic syndrome was the most common clinical diagnosis at age > 5 years, nephrotic syndrome was the most frequent diagnosis at age < 4 years. The most common pathological diagnosis as classified by pathogenesis in pediatric patients was primary glomerular disease (except IgA nephropathy), whereas IgA nephropathy was increased in AYA patients. Mesangial proliferative glomerulonephritis was the most common pathological diagnosis as classified by histopathology in both pediatric and AYA patients. Minor glomerular abnormalities were the most frequent histopathologic diagnoses of nephrotic syndrome in childhood, but their frequency decreased with age. Conclusion: To the best of our knowledge, this is the first report of clinicopathological features of pediatric and AYA patients in a large nationwide registry of renal biopsy. There were differences of clinical, pathological and histopathologic findings between pediatric and AYA patients.
KW - Adolescent
KW - Chronic kidney disease
KW - Cross-sectional analysis
KW - Nephrotic syndrome
KW - Young adult
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U2 - 10.1007/s10157-021-02077-w
DO - 10.1007/s10157-021-02077-w
M3 - Article
C2 - 34047871
AN - SCOPUS:85114130985
SN - 1342-1751
VL - 25
SP - 1018
EP - 1026
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
IS - 9
ER -