Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications

Sadao Suga, Tetsushi Yoshikawa, Yoshizo Asano, Toru Kozawa, Toshihiko Nakashima, Ikuko Kobayashi, Takehiko Yazaki, Hiroko Yamamoto, Yaji Kajita, Takao Ozaki, Yataka Nishimura, Tarsuhiro Yamanaka, Akira Yamada, Jiro Imanishi

研究成果: Article

141 引用 (Scopus)

抄録

Twenty‐one infants who had virologically confirmed exanthem subitum and central nervous system (CNS) complications were studied to elucidate the clinical fearures, laboratory and virological findings, and outcome. The primary infection with human herpesvirus 6 was confirmed by isolation of the virus from blood, a significant rise in the antibody titeres to the virus, or both. All convulsive seizures (15 generalized and 6 focal) occurred during the pre‐eruptive stage of exanthem subitum. Four infants with encephalities/encephalopathy had more severe clinical features with abnormalities demonstrated on electroencephalograms and cerebral computed tomograms. All infants except those with encephalities/encephalopathy recovered without any sequelae. One infant with encephalities/encephalopathy developed epilepsy and another one died. Human herpesvirus 6 DNA amplified by the nested polymerase chain reaction method was detected in the cerebrospinal fluid of 6 infants, including 3 with encephalities/encephalopathy, of 11 parients examined by the fifthy day of the illness. These findings suggest thar CNS complications including encephalitis/encephalopathy occur at the pre‐eruptive stae of exanthem subitum, that human herpesvirus 6 invades the CNS in some patients, and that the outcome is not always benign.

元の言語English
ページ(範囲)597-603
ページ数7
ジャーナルAnnals of Neurology
33
発行部数6
DOI
出版物ステータスPublished - 01-01-1993
外部発表Yes

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Exanthema Subitum
Brain Diseases
Exanthema
Human Herpesvirus 6
Central Nervous System
Viruses
Sick Leave
Encephalitis
Cerebrospinal Fluid
Electroencephalography
Epilepsy
Seizures
Polymerase Chain Reaction
Antibodies
DNA
Infection

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Suga, Sadao ; Yoshikawa, Tetsushi ; Asano, Yoshizo ; Kozawa, Toru ; Nakashima, Toshihiko ; Kobayashi, Ikuko ; Yazaki, Takehiko ; Yamamoto, Hiroko ; Kajita, Yaji ; Ozaki, Takao ; Nishimura, Yataka ; Yamanaka, Tarsuhiro ; Yamada, Akira ; Imanishi, Jiro. / Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications. :: Annals of Neurology. 1993 ; 巻 33, 番号 6. pp. 597-603.
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abstract = "Twenty‐one infants who had virologically confirmed exanthem subitum and central nervous system (CNS) complications were studied to elucidate the clinical fearures, laboratory and virological findings, and outcome. The primary infection with human herpesvirus 6 was confirmed by isolation of the virus from blood, a significant rise in the antibody titeres to the virus, or both. All convulsive seizures (15 generalized and 6 focal) occurred during the pre‐eruptive stage of exanthem subitum. Four infants with encephalities/encephalopathy had more severe clinical features with abnormalities demonstrated on electroencephalograms and cerebral computed tomograms. All infants except those with encephalities/encephalopathy recovered without any sequelae. One infant with encephalities/encephalopathy developed epilepsy and another one died. Human herpesvirus 6 DNA amplified by the nested polymerase chain reaction method was detected in the cerebrospinal fluid of 6 infants, including 3 with encephalities/encephalopathy, of 11 parients examined by the fifthy day of the illness. These findings suggest thar CNS complications including encephalitis/encephalopathy occur at the pre‐eruptive stae of exanthem subitum, that human herpesvirus 6 invades the CNS in some patients, and that the outcome is not always benign.",
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Suga, S, Yoshikawa, T, Asano, Y, Kozawa, T, Nakashima, T, Kobayashi, I, Yazaki, T, Yamamoto, H, Kajita, Y, Ozaki, T, Nishimura, Y, Yamanaka, T, Yamada, A & Imanishi, J 1993, 'Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications', Annals of Neurology, 巻. 33, 番号 6, pp. 597-603. https://doi.org/10.1002/ana.410330607

Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications. / Suga, Sadao; Yoshikawa, Tetsushi; Asano, Yoshizo; Kozawa, Toru; Nakashima, Toshihiko; Kobayashi, Ikuko; Yazaki, Takehiko; Yamamoto, Hiroko; Kajita, Yaji; Ozaki, Takao; Nishimura, Yataka; Yamanaka, Tarsuhiro; Yamada, Akira; Imanishi, Jiro.

:: Annals of Neurology, 巻 33, 番号 6, 01.01.1993, p. 597-603.

研究成果: Article

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AU - Suga, Sadao

AU - Yoshikawa, Tetsushi

AU - Asano, Yoshizo

AU - Kozawa, Toru

AU - Nakashima, Toshihiko

AU - Kobayashi, Ikuko

AU - Yazaki, Takehiko

AU - Yamamoto, Hiroko

AU - Kajita, Yaji

AU - Ozaki, Takao

AU - Nishimura, Yataka

AU - Yamanaka, Tarsuhiro

AU - Yamada, Akira

AU - Imanishi, Jiro

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N2 - Twenty‐one infants who had virologically confirmed exanthem subitum and central nervous system (CNS) complications were studied to elucidate the clinical fearures, laboratory and virological findings, and outcome. The primary infection with human herpesvirus 6 was confirmed by isolation of the virus from blood, a significant rise in the antibody titeres to the virus, or both. All convulsive seizures (15 generalized and 6 focal) occurred during the pre‐eruptive stage of exanthem subitum. Four infants with encephalities/encephalopathy had more severe clinical features with abnormalities demonstrated on electroencephalograms and cerebral computed tomograms. All infants except those with encephalities/encephalopathy recovered without any sequelae. One infant with encephalities/encephalopathy developed epilepsy and another one died. Human herpesvirus 6 DNA amplified by the nested polymerase chain reaction method was detected in the cerebrospinal fluid of 6 infants, including 3 with encephalities/encephalopathy, of 11 parients examined by the fifthy day of the illness. These findings suggest thar CNS complications including encephalitis/encephalopathy occur at the pre‐eruptive stae of exanthem subitum, that human herpesvirus 6 invades the CNS in some patients, and that the outcome is not always benign.

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