Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications

Sadao Suga, Tetsushi Yoshikawa, Yoshizo Asano, Toru Kozawa, Toshihiko Nakashima, Ikuko Kobayashi, Takehiko Yazaki, Hiroko Yamamoto, Yaji Kajita, Takao Ozaki, Yataka Nishimura, Tarsuhiro Yamanaka, Akira Yamada, Jiro Imanishi

研究成果: Article査読

145 被引用数 (Scopus)

抄録

Twenty‐one infants who had virologically confirmed exanthem subitum and central nervous system (CNS) complications were studied to elucidate the clinical fearures, laboratory and virological findings, and outcome. The primary infection with human herpesvirus 6 was confirmed by isolation of the virus from blood, a significant rise in the antibody titeres to the virus, or both. All convulsive seizures (15 generalized and 6 focal) occurred during the pre‐eruptive stage of exanthem subitum. Four infants with encephalities/encephalopathy had more severe clinical features with abnormalities demonstrated on electroencephalograms and cerebral computed tomograms. All infants except those with encephalities/encephalopathy recovered without any sequelae. One infant with encephalities/encephalopathy developed epilepsy and another one died. Human herpesvirus 6 DNA amplified by the nested polymerase chain reaction method was detected in the cerebrospinal fluid of 6 infants, including 3 with encephalities/encephalopathy, of 11 parients examined by the fifthy day of the illness. These findings suggest thar CNS complications including encephalitis/encephalopathy occur at the pre‐eruptive stae of exanthem subitum, that human herpesvirus 6 invades the CNS in some patients, and that the outcome is not always benign.

本文言語English
ページ(範囲)597-603
ページ数7
ジャーナルAnnals of Neurology
33
6
DOI
出版ステータスPublished - 06-1993
外部発表はい

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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