Clinical characterization of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia pattern

Yoshitaka Totani, Yuji Saito, Hiromi Miyachi, Yukiko Yoneda, Hideyasu Shimizu, Tami Hoshino, Masamichi Hayashi, Yasuhiro Uchiyama, Sumito Isogai, Kiyoshi Matsui, Yasushi Hashimoto, Masaya Umemoto, Fumihiko Sasaki, Mitsushi Okazawa, Hiroki Sakakibara

研究成果: Article

6 引用 (Scopus)

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OBJECTIVE AND METHODS: To assess the clinical significance of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia (NSIP) pattern (IP/NSIP groups), we measured the levels of serum (n = 14) and bronchoalveolar lavage fluid (BALF, n = 10) CA19-9 in IP/NSIP groups. RESULT: The serum levels of CA19-9 did not correlate with the serum levels of LDH, of KL-6, or of SP-D or with the intensity of chest Ga-67 scintigraphy. There were no significant differences between the serum CA19-9 levels before therapy and those after therapy in improving patients. The levels of CA19-9 in fibrotic NSIP groups (serum:n = 7, 138.3 + /- 79.6 U/ml BALF: n = 5, 845.8 + /- 334.2 U/ml) were significantly higher than those in cellular NSIP groups (serum: n = 7, 12.8 +/-2.1 U/ml, BALF: n = 5, 40.8 +/- 16.2 U/ml). Immunohistochemical stains of CA19-9 showed the strong positivity in the bronchiolar epitheliums located in severe fibrotic lesions and the mucus within the lumens of microscopic honeycomb. The serum levels of CA19-9 were increased in both worsening patients. CONCLUSION: We speculated that the serum levels of CA19-9 may reflect the progression of lung fibrosis but not the disease activity in IP-NSIP groups.

元の言語English
ページ(範囲)77-83
ページ数7
ジャーナルNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
43
発行部数2
出版物ステータスPublished - 01-01-2005

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Interstitial Lung Diseases
Serum
Pulmonary Surfactant-Associated Protein D
Bronchoalveolar Lavage Fluid
Mucus
Radionuclide Imaging
Fibrosis
Coloring Agents
Thorax
Lung
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Totani, Yoshitaka ; Saito, Yuji ; Miyachi, Hiromi ; Yoneda, Yukiko ; Shimizu, Hideyasu ; Hoshino, Tami ; Hayashi, Masamichi ; Uchiyama, Yasuhiro ; Isogai, Sumito ; Matsui, Kiyoshi ; Hashimoto, Yasushi ; Umemoto, Masaya ; Sasaki, Fumihiko ; Okazawa, Mitsushi ; Sakakibara, Hiroki. / Clinical characterization of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia pattern. :: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2005 ; 巻 43, 番号 2. pp. 77-83.
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title = "Clinical characterization of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia pattern",
abstract = "OBJECTIVE AND METHODS: To assess the clinical significance of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia (NSIP) pattern (IP/NSIP groups), we measured the levels of serum (n = 14) and bronchoalveolar lavage fluid (BALF, n = 10) CA19-9 in IP/NSIP groups. RESULT: The serum levels of CA19-9 did not correlate with the serum levels of LDH, of KL-6, or of SP-D or with the intensity of chest Ga-67 scintigraphy. There were no significant differences between the serum CA19-9 levels before therapy and those after therapy in improving patients. The levels of CA19-9 in fibrotic NSIP groups (serum:n = 7, 138.3 + /- 79.6 U/ml BALF: n = 5, 845.8 + /- 334.2 U/ml) were significantly higher than those in cellular NSIP groups (serum: n = 7, 12.8 +/-2.1 U/ml, BALF: n = 5, 40.8 +/- 16.2 U/ml). Immunohistochemical stains of CA19-9 showed the strong positivity in the bronchiolar epitheliums located in severe fibrotic lesions and the mucus within the lumens of microscopic honeycomb. The serum levels of CA19-9 were increased in both worsening patients. CONCLUSION: We speculated that the serum levels of CA19-9 may reflect the progression of lung fibrosis but not the disease activity in IP-NSIP groups.",
author = "Yoshitaka Totani and Yuji Saito and Hiromi Miyachi and Yukiko Yoneda and Hideyasu Shimizu and Tami Hoshino and Masamichi Hayashi and Yasuhiro Uchiyama and Sumito Isogai and Kiyoshi Matsui and Yasushi Hashimoto and Masaya Umemoto and Fumihiko Sasaki and Mitsushi Okazawa and Hiroki Sakakibara",
year = "2005",
month = "1",
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Totani, Y, Saito, Y, Miyachi, H, Yoneda, Y, Shimizu, H, Hoshino, T, Hayashi, M, Uchiyama, Y, Isogai, S, Matsui, K, Hashimoto, Y, Umemoto, M, Sasaki, F, Okazawa, M & Sakakibara, H 2005, 'Clinical characterization of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia pattern', Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 巻. 43, 番号 2, pp. 77-83.

Clinical characterization of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia pattern. / Totani, Yoshitaka; Saito, Yuji; Miyachi, Hiromi; Yoneda, Yukiko; Shimizu, Hideyasu; Hoshino, Tami; Hayashi, Masamichi; Uchiyama, Yasuhiro; Isogai, Sumito; Matsui, Kiyoshi; Hashimoto, Yasushi; Umemoto, Masaya; Sasaki, Fumihiko; Okazawa, Mitsushi; Sakakibara, Hiroki.

:: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 巻 43, 番号 2, 01.01.2005, p. 77-83.

研究成果: Article

TY - JOUR

T1 - Clinical characterization of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia pattern

AU - Totani, Yoshitaka

AU - Saito, Yuji

AU - Miyachi, Hiromi

AU - Yoneda, Yukiko

AU - Shimizu, Hideyasu

AU - Hoshino, Tami

AU - Hayashi, Masamichi

AU - Uchiyama, Yasuhiro

AU - Isogai, Sumito

AU - Matsui, Kiyoshi

AU - Hashimoto, Yasushi

AU - Umemoto, Masaya

AU - Sasaki, Fumihiko

AU - Okazawa, Mitsushi

AU - Sakakibara, Hiroki

PY - 2005/1/1

Y1 - 2005/1/1

N2 - OBJECTIVE AND METHODS: To assess the clinical significance of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia (NSIP) pattern (IP/NSIP groups), we measured the levels of serum (n = 14) and bronchoalveolar lavage fluid (BALF, n = 10) CA19-9 in IP/NSIP groups. RESULT: The serum levels of CA19-9 did not correlate with the serum levels of LDH, of KL-6, or of SP-D or with the intensity of chest Ga-67 scintigraphy. There were no significant differences between the serum CA19-9 levels before therapy and those after therapy in improving patients. The levels of CA19-9 in fibrotic NSIP groups (serum:n = 7, 138.3 + /- 79.6 U/ml BALF: n = 5, 845.8 + /- 334.2 U/ml) were significantly higher than those in cellular NSIP groups (serum: n = 7, 12.8 +/-2.1 U/ml, BALF: n = 5, 40.8 +/- 16.2 U/ml). Immunohistochemical stains of CA19-9 showed the strong positivity in the bronchiolar epitheliums located in severe fibrotic lesions and the mucus within the lumens of microscopic honeycomb. The serum levels of CA19-9 were increased in both worsening patients. CONCLUSION: We speculated that the serum levels of CA19-9 may reflect the progression of lung fibrosis but not the disease activity in IP-NSIP groups.

AB - OBJECTIVE AND METHODS: To assess the clinical significance of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia (NSIP) pattern (IP/NSIP groups), we measured the levels of serum (n = 14) and bronchoalveolar lavage fluid (BALF, n = 10) CA19-9 in IP/NSIP groups. RESULT: The serum levels of CA19-9 did not correlate with the serum levels of LDH, of KL-6, or of SP-D or with the intensity of chest Ga-67 scintigraphy. There were no significant differences between the serum CA19-9 levels before therapy and those after therapy in improving patients. The levels of CA19-9 in fibrotic NSIP groups (serum:n = 7, 138.3 + /- 79.6 U/ml BALF: n = 5, 845.8 + /- 334.2 U/ml) were significantly higher than those in cellular NSIP groups (serum: n = 7, 12.8 +/-2.1 U/ml, BALF: n = 5, 40.8 +/- 16.2 U/ml). Immunohistochemical stains of CA19-9 showed the strong positivity in the bronchiolar epitheliums located in severe fibrotic lesions and the mucus within the lumens of microscopic honeycomb. The serum levels of CA19-9 were increased in both worsening patients. CONCLUSION: We speculated that the serum levels of CA19-9 may reflect the progression of lung fibrosis but not the disease activity in IP-NSIP groups.

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JO - Respiratory Investigation

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