Clinical comparison study between a newly developed optical-based fractional flow reserve device and the conventional fractional flow reserve device

Yuki Saka, Akihito Tanaka, Hideki Ishii, Hiroaki Takashima, Akihiro Suzuki, Yusuke Nakano, Shinichiro Sakurai, Hirohiko Ando, Toyoaki Murohara, Tetsuya Amano

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Background Fractional flow reserve (FFR) measurement is the gold standard for identifying the functional severity of coronary artery disease. Although we can use newly developed pressure wires with optical fibers are now available, their safety and accuracy for FFR measurement are not clear. Therefore, we planned a clinical comparison study between pressure wires with optical fibers and the conventional FFR device. Methods We prospectively enrolled 51 patients (51 lesions) with intermediate coronary artery stenosis. For these lesions, FFR measurements with pressure wires with optical fibers were compared with those obtained with a conventional wire. Results All procedures were successfully completed without any complications. The procedure time with pressure wires with optical fibers and a conventional wire was 6.8 ± 3.0 and 6.9 ± 2.6 minutes (P = 0.89), respectively. There was no significant difference in FFR values between pressure wires with optical fibers and a conventional wire (0.83 ± 0.10 vs. 0.83 ± 0.12, P = 0.66). An excellent correlation was observed between FFR obtained with pressure wires with optical fibers and FFR obtained with a conventional wire (r = 0.81, P < 0.001). The pressure drift before and after FFR measurements was not significantly different between pressure wires with optical fibers and a convention wire (-0.01 ± 0.02 vs. -0.02 ± 0.06, P = 0.42). There was no significant difference in pressure drift defined as >0.03 or <-0.03 between pressure wires with optical fibers and a convention wire (13.7 vs. 17.6%, P = 0.79). Conclusion Excellent correlations were observed between FFR values measured using pressure wires with optical fibers and a conventional wire. Furthermore, measurement of FFR with pressure wires with optical fibers was as well tolerated and reliable as that with a conventional wire.

本文言語English
ページ(範囲)342-347
ページ数6
ジャーナルCoronary Artery Disease
DOI
出版ステータスAccepted/In press - 2020
外部発表はい

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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