Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes

Shinichi Watanabe; Ken Iozumi; Masatoshi Abe; Yoshiko Ito; Takashi Uesugi; Takashi Onoduka; Ichiro Kato; Fumihiro Kato; Kazuo Kodama; Hidetoshi Takahashi; Osamu Takeda; Koki Tomizawa; Yasuki Tateishi; Mizue Fujii; Jun Mayama; Fumio Muramoto; Hidemi Yasuda; Kiyomitsu Yamanaka; Tsunao Oh-i; Hiroko Kasai; Ryoji Tsuboi; Naoko Hattori; Ryuji Maruyama; Tokuya Omi; Harunari Shimoyama; Ichiro Nakasu; Emiko Watanabe-Okada; Shuhei Nishimoto; Takashi Mochizuki; Masao Fukuzawa; Mariko Seishima; Kazumitsu Sugiura; Osamu Yamamoto; Masahisa Shindo; Hiroe Kiryu; Masahiro Kusuhara; Motoi Takenaka

doi:10.1111/1346-8138.16035

Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes

Shinichi Watanabe, Ken Iozumi, Masatoshi Abe, Yoshiko Ito, Takashi Uesugi, Takashi Onoduka, Ichiro Kato, Fumihiro Kato, Kazuo Kodama, Hidetoshi Takahashi, Osamu Takeda, Koki Tomizawa, Yasuki Tateishi, Mizue Fujii, Jun Mayama, Fumio Muramoto, Hidemi Yasuda, Kiyomitsu Yamanaka, Tsunao Oh-i, Hiroko KasaiRyoji Tsuboi, Naoko Hattori, Ryuji Maruyama, Tokuya Omi, Harunari Shimoyama, Ichiro Nakasu, Emiko Watanabe-Okada, Shuhei Nishimoto, Takashi Mochizuki, Masao Fukuzawa, Mariko Seishima, Kazumitsu Sugiura, Osamu Yamamoto, Masahisa Shindo, Hiroe Kiryu, Masahiro Kusuhara, Motoi Takenaka

皮膚科学

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

5 被引用数 (Scopus)

抄録

Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory to oral drugs as with dermatophytoma. We evaluated the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes. Of the 223 subjects who were enrolled in a previous study, a post-hoc analysis of 82 subjects with longitudinal spikes was performed in this study. The opacity ratio of longitudinal spikes was decreased over time from 8.1 to 0.9 at the final assessment. In addition, the longitudinal spike disappearance rate increased early after the application to 81.7% at the final assessment. Therefore, 10% efinaconazole solution can be a first-line drug for longitudinal spikes, which have been regarded as refractory to oral drugs.

本文言語	英語
ページ（範囲）	1474-1481
ページ数	8
ジャーナル	Journal of Dermatology
巻	48
号	10
DOI	https://doi.org/10.1111/1346-8138.16035
出版ステータス	出版済み - 10-2021

All Science Journal Classification (ASJC) codes

皮膚病学

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10.1111/1346-8138.16035

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Watanabe, S., Iozumi, K., Abe, M., Ito, Y., Uesugi, T., Onoduka, T., Kato, I., Kato, F., Kodama, K., Takahashi, H., Takeda, O., Tomizawa, K., Tateishi, Y., Fujii, M., Mayama, J., Muramoto, F., Yasuda, H., Yamanaka, K., Oh-i, T., ... Takenaka, M. (2021). Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes. Journal of Dermatology, 48(10), 1474-1481. https://doi.org/10.1111/1346-8138.16035

@article{5b69965526974064b9292bea52089c26,

title = "Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes",

abstract = "Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory to oral drugs as with dermatophytoma. We evaluated the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes. Of the 223 subjects who were enrolled in a previous study, a post-hoc analysis of 82 subjects with longitudinal spikes was performed in this study. The opacity ratio of longitudinal spikes was decreased over time from 8.1 to 0.9 at the final assessment. In addition, the longitudinal spike disappearance rate increased early after the application to 81.7% at the final assessment. Therefore, 10% efinaconazole solution can be a first-line drug for longitudinal spikes, which have been regarded as refractory to oral drugs.",

author = "Shinichi Watanabe and Ken Iozumi and Masatoshi Abe and Yoshiko Ito and Takashi Uesugi and Takashi Onoduka and Ichiro Kato and Fumihiro Kato and Kazuo Kodama and Hidetoshi Takahashi and Osamu Takeda and Koki Tomizawa and Yasuki Tateishi and Mizue Fujii and Jun Mayama and Fumio Muramoto and Hidemi Yasuda and Kiyomitsu Yamanaka and Tsunao Oh-i and Hiroko Kasai and Ryoji Tsuboi and Naoko Hattori and Ryuji Maruyama and Tokuya Omi and Harunari Shimoyama and Ichiro Nakasu and Emiko Watanabe-Okada and Shuhei Nishimoto and Takashi Mochizuki and Masao Fukuzawa and Mariko Seishima and Kazumitsu Sugiura and Osamu Yamamoto and Masahisa Shindo and Hiroe Kiryu and Masahiro Kusuhara and Motoi Takenaka",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association",

year = "2021",

month = oct,

doi = "10.1111/1346-8138.16035",

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Watanabe, S, Iozumi, K, Abe, M, Ito, Y, Uesugi, T, Onoduka, T, Kato, I, Kato, F, Kodama, K, Takahashi, H, Takeda, O, Tomizawa, K, Tateishi, Y, Fujii, M, Mayama, J, Muramoto, F, Yasuda, H, Yamanaka, K, Oh-i, T, Kasai, H, Tsuboi, R, Hattori, N, Maruyama, R, Omi, T, Shimoyama, H, Nakasu, I, Watanabe-Okada, E, Nishimoto, S, Mochizuki, T, Fukuzawa, M, Seishima, M, Sugiura, K, Yamamoto, O, Shindo, M, Kiryu, H, Kusuhara, M & Takenaka, M 2021, 'Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes', Journal of Dermatology, vol. 48, no. 10, pp. 1474-1481. https://doi.org/10.1111/1346-8138.16035

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T1 - Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes

AU - Watanabe, Shinichi

AU - Iozumi, Ken

AU - Abe, Masatoshi

AU - Ito, Yoshiko

AU - Uesugi, Takashi

AU - Onoduka, Takashi

AU - Kato, Ichiro

AU - Kato, Fumihiro

AU - Kodama, Kazuo

AU - Takahashi, Hidetoshi

AU - Takeda, Osamu

AU - Tomizawa, Koki

AU - Tateishi, Yasuki

AU - Fujii, Mizue

AU - Mayama, Jun

AU - Muramoto, Fumio

AU - Yasuda, Hidemi

AU - Yamanaka, Kiyomitsu

AU - Oh-i, Tsunao

AU - Kasai, Hiroko

AU - Tsuboi, Ryoji

AU - Hattori, Naoko

AU - Maruyama, Ryuji

AU - Omi, Tokuya

AU - Shimoyama, Harunari

AU - Nakasu, Ichiro

AU - Watanabe-Okada, Emiko

AU - Nishimoto, Shuhei

AU - Mochizuki, Takashi

AU - Fukuzawa, Masao

AU - Seishima, Mariko

AU - Sugiura, Kazumitsu

AU - Yamamoto, Osamu

AU - Shindo, Masahisa

AU - Kiryu, Hiroe

AU - Kusuhara, Masahiro

AU - Takenaka, Motoi

PY - 2021/10

Y1 - 2021/10

N2 - Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory to oral drugs as with dermatophytoma. We evaluated the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes. Of the 223 subjects who were enrolled in a previous study, a post-hoc analysis of 82 subjects with longitudinal spikes was performed in this study. The opacity ratio of longitudinal spikes was decreased over time from 8.1 to 0.9 at the final assessment. In addition, the longitudinal spike disappearance rate increased early after the application to 81.7% at the final assessment. Therefore, 10% efinaconazole solution can be a first-line drug for longitudinal spikes, which have been regarded as refractory to oral drugs.

AB - Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory to oral drugs as with dermatophytoma. We evaluated the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes. Of the 223 subjects who were enrolled in a previous study, a post-hoc analysis of 82 subjects with longitudinal spikes was performed in this study. The opacity ratio of longitudinal spikes was decreased over time from 8.1 to 0.9 at the final assessment. In addition, the longitudinal spike disappearance rate increased early after the application to 81.7% at the final assessment. Therefore, 10% efinaconazole solution can be a first-line drug for longitudinal spikes, which have been regarded as refractory to oral drugs.

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AN - SCOPUS:85109285632

SN - 0385-2407

VL - 48

SP - 1474

EP - 1481

JO - Journal of Dermatology

JF - Journal of Dermatology

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Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes

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