Clinical features and testicular morphology in patients with Kallmann syndrome

Hidenori Nishio; Kentaro Mizuno; Yoshinobu Moritoki; Hideyuki Kamisawa; Yoshiyuki Kojima; Haruo Mizuno; Kenjiro Kohri; Yutaro Hayashi

doi:10.1016/j.urology.2011.10.032

Clinical features and testicular morphology in patients with Kallmann syndrome

Hidenori Nishio, Kentaro Mizuno, Yoshinobu Moritoki, Hideyuki Kamisawa, Yoshiyuki Kojima, Haruo Mizuno, Kenjiro Kohri, Yutaro Hayashi

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (Scopus)

抄録

Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development.

本文言語	英語
ページ（範囲）	684-686
ページ数	3
ジャーナル	Urology
巻	79
号	3
DOI	https://doi.org/10.1016/j.urology.2011.10.032
出版ステータス	出版済み - 03-2012
外部発表	はい

All Science Journal Classification (ASJC) codes

泌尿器学

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10.1016/j.urology.2011.10.032

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title = "Clinical features and testicular morphology in patients with Kallmann syndrome",

abstract = "Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development.",

author = "Hidenori Nishio and Kentaro Mizuno and Yoshinobu Moritoki and Hideyuki Kamisawa and Yoshiyuki Kojima and Haruo Mizuno and Kenjiro Kohri and Yutaro Hayashi",

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T1 - Clinical features and testicular morphology in patients with Kallmann syndrome

AU - Nishio, Hidenori

AU - Mizuno, Kentaro

AU - Moritoki, Yoshinobu

AU - Kamisawa, Hideyuki

AU - Kojima, Yoshiyuki

AU - Mizuno, Haruo

AU - Kohri, Kenjiro

AU - Hayashi, Yutaro

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N2 - Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development.

AB - Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development.

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Clinical features and testicular morphology in patients with Kallmann syndrome

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