Clinical Features, Genome Epidemiology, and Antimicrobial Resistance Profiles of Aeromonas spp. Causing Human Infections: A Multicenter Prospective Cohort Study

Aki Sakurai, Masahiro Suzuki, Daisuke Ohkushi, Sohei Harada, Naoto Hosokawa, Kazuhiro Ishikawa, Takayuki Sakurai, Takuma Ishihara, Hiroki Sasazawa, Takeru Yamamoto, Kazumi Takehana, Saho Koyano, Yohei Doi

研究成果: ジャーナルへの寄稿学術論文査読

抄録

Background: The genus Aeromonas is increasingly implicated in human infections, but knowledge of its clinical characteristics and antimicrobial resistance profiles has been limited owing to its complex taxonomy. Methods: We conducted a multicenter prospective cohort study of patients with Aeromonas infections at hospitals across Japan. Patients were eligible for inclusion if they had an Aeromonas spp. strain in a clinical culture and were considered infected at the culture site. Clinical data were collected, and isolates underwent susceptibility testing and whole-genome sequencing. Results: A total of 144 patients were included. Hepatobiliary infection accounted for a majority of infections (73% [105 of 144]), which mostly occurred in elderly patients with comorbid conditions, including hepatobiliary complications. The all-cause 30-day mortality rate was 10.0% (95% confidence interval, 4.9%-14.8%). By whole-genome sequencing, 141 strains (98%) belonged to 4 Aeromonas species - A caviae, A hydrophila, A veronii, and A dhakensis - with significant intraspecies diversity. A caviae was predominant in all infection sites except skin and soft tissue, for which A hydrophila was the prevailing species. The genes encoding chromosomally mediated class B, C, and D β-lactamases were harbored by 92%-100% of the isolates in a species-specific manner, but they often lacked association with resistance phenotypes. The activity of cefepime was reliable. All isolates of A hydrophila and A dhakensis carried an mcr-3-like colistin resistance gene and showed reduced susceptibility to colistin. Conclusions: Hepatobiliary tract was the most common infection site of Aeromonas spp., with A caviae being the dominant causative species. The resistance genotype and phenotype were often incongruent for β-lactam agents.

本文言語英語
論文番号ofad587
ジャーナルOpen Forum Infectious Diseases
10
12
DOI
出版ステータス出版済み - 01-12-2023

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 感染症

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