Clinical features of hhv-6b encephalitis: Difference between primary infection and reactivation

研究成果: Chapter

抜粋

Human herpesvirus 6 (HHV-6) belongs to β-herpesvirinae subfamily and is now divided into two different species: HHV-6A and HHV-6B. HHB-6B is the etiologic agent for exanthema subitum. This virus has been suggested to have neurovirulence based on the in vivo and in vitro analyses. Complex type of febrile seizure and encephalitis are important complications at the time of primary viral infection. Primary HHV-6B infection has been associated with various types of encephalitis; indeed, recently, patients with AESD have been dominant. According to the previous studies, the host immune response may play an important role in the pathogenesis of HHV-6B encephalitis at the time of primary viral infection. In contrast to the primary viral infection, virus reactivation can cause limbic encephalitis in immunocompromised patients such as transplant recipients. HHV-6B replication in limbic area may play an important role in causing posttransplant acute limbic encephalitis. Detection of high copies of viral DNA in cerebrospinal fluid is useful for diagnosis of HHV-6B encephalitis in transplant recipients. Additionally, antiviral drugs such as ganciclovir and foscarnet should be administered in these patients.

元の言語English
ホスト出版物のタイトルAcute Encephalopathy and Encephalitis in Infancy and Its Related Disorders
出版者Elsevier Inc.
ページ157-162
ページ数6
ISBN(電子版)9780323530903
ISBN(印刷物)9780323530880
DOI
出版物ステータスPublished - 01-01-2018

All Science Journal Classification (ASJC) codes

  • Medicine(all)

フィンガープリント Clinical features of hhv-6b encephalitis: Difference between primary infection and reactivation' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Yoshikawa, T. (2018). Clinical features of hhv-6b encephalitis: Difference between primary infection and reactivation. : Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders (pp. 157-162). Elsevier Inc.. https://doi.org/10.1016/B978-0-323-53088-0.00021-X