Clinical implication of human leukocyte antigen (HLA)-F expression in breast cancer

Aya Harada, Sumiya Ishigami, Yuko Kijima, Akihiro Nakajo, Takaaki Arigami, Hiroshi Kurahara, Yoshiaki Kita, Heiji Yoshinaka, Shoji Natsugoe

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Human leukocyte antigen (HLA)-F is one of the non-classical HLA class I molecules that protects the fetus in pregnancy. HLA-F expression was immunohistochemically examined and the association between clinical parameters and HLA-F expression was analyzed. Cancerous HLA-F and stromal HLA-F-positive infiltrating cells were detected in 91 (40.0%) and 186 (81.6%) cases, respectively. HLA-F positivity in cancer cells was significantly associated with tumor size (P<0.05). There was a weak correlation between HLA-F positivity of cancer cells and HLA-F positive infiltrative cells (P<0.01, r=0.11). HLA-F positivity did not affect patients' survival in 209 breast cancer. However, confined to stage II breast cancer, the HLA-F positive group showed significantly poorer outcomes than the HLA-F negative group (P<0.05). The present study provides the first evidence that HLA-F positivity in breast carcinoma affects clinicopathological factors and could be selected as a prognostic marker for limited clinical stage.

本文言語English
ページ(範囲)569-574
ページ数6
ジャーナルPathology International
65
11
DOI
出版ステータスPublished - 11-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 病理学および法医学

フィンガープリント

「Clinical implication of human leukocyte antigen (HLA)-F expression in breast cancer」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル