Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections

Ryan K. Shields; Brian A. Potoski; Ghady Haidar; Binghua Hao; Yohei Doi; Liang Chen; Ellen G. Press; Barry N. Kreiswirth; Cornelius J. Clancy; M. Hong Nguyen

doi:10.1093/cid/ciw636

Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections

Ryan K. Shields
, Brian A. Potoski
, Ghady Haidar
, Binghua Hao
, Yohei Doi
, Liang Chen
, Ellen G. Press
, Barry N. Kreiswirth
, Cornelius J. Clancy
, M. Hong Nguyen

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

407 被引用数 (Scopus)

抄録

Thirty-seven carbapenem-resistant Enterobacteriaceae (CRE)-infected patients were treated with ceftazidime-avibactam. Clinical success and survival rates at 30 days were 59% (22/37) and 76% (28/37), respectively. In 23% (5/22) of clinical successes, CRE infections recurred within 90 days. Microbiologic failure rate was 27% (10/37). Ceftazidime-avibactam resistance was detected in 30% (3/10) of microbiologic failures.

本文言語	英語
ページ（範囲）	1615-1618
ページ数	4
ジャーナル	Clinical Infectious Diseases
巻	63
号	12
DOI	https://doi.org/10.1093/cid/ciw636
出版ステータス	出版済み - 15-12-2016
外部発表	はい

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この成果は、次の持続可能な開発目標に貢献しています

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All Science Journal Classification (ASJC) codes

微生物学（医療）
感染症

文献へのアクセス

10.1093/cid/ciw636

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「Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Shields, R. K., Potoski, B. A., Haidar, G., Hao, B., Doi, Y., Chen, L., Press, E. G., Kreiswirth, B. N., Clancy, C. J., & Nguyen, M. H. (2016). Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections. Clinical Infectious Diseases, 63(12), 1615-1618. https://doi.org/10.1093/cid/ciw636

@article{bfdf1e1245454a5e9de1632563562990,

title = "Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections",

abstract = "Thirty-seven carbapenem-resistant Enterobacteriaceae (CRE)-infected patients were treated with ceftazidime-avibactam. Clinical success and survival rates at 30 days were 59\% (22/37) and 76\% (28/37), respectively. In 23\% (5/22) of clinical successes, CRE infections recurred within 90 days. Microbiologic failure rate was 27\% (10/37). Ceftazidime-avibactam resistance was detected in 30\% (3/10) of microbiologic failures.",

keywords = "Klebsiella pneumoniae carbapenemase, carbapenem-resistant Enterobacteriaceae, ceftazidime-avibactam resistance",

author = "Shields, \{Ryan K.\} and Potoski, \{Brian A.\} and Ghady Haidar and Binghua Hao and Yohei Doi and Liang Chen and Press, \{Ellen G.\} and Kreiswirth, \{Barry N.\} and Clancy, \{Cornelius J.\} and Nguyen, \{M. Hong\}",

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doi = "10.1093/cid/ciw636",

language = "English",

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Shields, RK, Potoski, BA, Haidar, G, Hao, B, Doi, Y, Chen, L, Press, EG, Kreiswirth, BN, Clancy, CJ & Nguyen, MH 2016, 'Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections', Clinical Infectious Diseases, vol. 63, no. 12, pp. 1615-1618. https://doi.org/10.1093/cid/ciw636

Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections. / Shields, Ryan K.; Potoski, Brian A.; Haidar, Ghady その他.
In: Clinical Infectious Diseases, Vol. 63, No. 12, 15.12.2016, p. 1615-1618.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

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T1 - Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections

AU - Shields, Ryan K.

AU - Potoski, Brian A.

AU - Haidar, Ghady

AU - Hao, Binghua

AU - Doi, Yohei

AU - Chen, Liang

AU - Press, Ellen G.

AU - Kreiswirth, Barry N.

AU - Clancy, Cornelius J.

AU - Nguyen, M. Hong

PY - 2016/12/15

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N2 - Thirty-seven carbapenem-resistant Enterobacteriaceae (CRE)-infected patients were treated with ceftazidime-avibactam. Clinical success and survival rates at 30 days were 59% (22/37) and 76% (28/37), respectively. In 23% (5/22) of clinical successes, CRE infections recurred within 90 days. Microbiologic failure rate was 27% (10/37). Ceftazidime-avibactam resistance was detected in 30% (3/10) of microbiologic failures.

AB - Thirty-seven carbapenem-resistant Enterobacteriaceae (CRE)-infected patients were treated with ceftazidime-avibactam. Clinical success and survival rates at 30 days were 59% (22/37) and 76% (28/37), respectively. In 23% (5/22) of clinical successes, CRE infections recurred within 90 days. Microbiologic failure rate was 27% (10/37). Ceftazidime-avibactam resistance was detected in 30% (3/10) of microbiologic failures.

KW - Klebsiella pneumoniae carbapenemase

KW - carbapenem-resistant Enterobacteriaceae

KW - ceftazidime-avibactam resistance

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