TY - JOUR
T1 - Clinical outcomes of calcified nodules detected by optical coherence tomography
T2 - a sub-analysis of the CLIMA study
AU - Prati, Francesco
AU - Gatto, Laura
AU - Fabbiocchi, Franco
AU - Vergallo, Rocco
AU - Paoletti, Giulia
AU - Ruscica, Giovanni
AU - Marco, Valeria
AU - Romagnoli, Enrico
AU - Boi, Alberto
AU - Fineschi, Massimo
AU - Calligaris, Giuseppe
AU - Tamburino, Corrado
AU - Crea, Filippo
AU - Ozaki, Yukio
AU - Alfonso, Fernando
AU - Arbustini, Eloisa
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2020/8/28
Y1 - 2020/8/28
N2 - AIMS: The goal of the present post hoc analysis of the CLIMA registry was to establish the relationship between calcified nodules (CNs) with (CND) or without (CNWD) disruption of the superficial intimal fibrous layer and one-year occurrence of target lesion myocardial infarction (MI) and/or cardiac death. METHODS AND RESULTS: CND and CNWD were identified based on the presence or absence of superficial irregularities indicative of disruption of the intimal fibrous layer, with possible overlying local thrombus. In total, 222 CNs were found in the 1,776 non-culprit LAD plaques. CND had larger maximum calcific arc and smaller lumen area. Cardiac death and MI occurred in 20% of patients in the CND group versus 2.7% in the CNWD group and 3.3% in the group without CN (p<0.001). This figure was mainly due to the 13.3% incidence of cardiac death in the CND group versus 2.0% in the CNWD group and versus 2.2% in the group without CN (p<0.001). The presence of CND was confirmed as an independent predictor of events (HR 6.58, 95% CI: 2.7-15.8, p<0.001). CONCLUSIONS: The presence of CND was associated with a high one-year incidence of cardiac death and/or target lesion MI.
AB - AIMS: The goal of the present post hoc analysis of the CLIMA registry was to establish the relationship between calcified nodules (CNs) with (CND) or without (CNWD) disruption of the superficial intimal fibrous layer and one-year occurrence of target lesion myocardial infarction (MI) and/or cardiac death. METHODS AND RESULTS: CND and CNWD were identified based on the presence or absence of superficial irregularities indicative of disruption of the intimal fibrous layer, with possible overlying local thrombus. In total, 222 CNs were found in the 1,776 non-culprit LAD plaques. CND had larger maximum calcific arc and smaller lumen area. Cardiac death and MI occurred in 20% of patients in the CND group versus 2.7% in the CNWD group and 3.3% in the group without CN (p<0.001). This figure was mainly due to the 13.3% incidence of cardiac death in the CND group versus 2.0% in the CNWD group and versus 2.2% in the group without CN (p<0.001). The presence of CND was confirmed as an independent predictor of events (HR 6.58, 95% CI: 2.7-15.8, p<0.001). CONCLUSIONS: The presence of CND was associated with a high one-year incidence of cardiac death and/or target lesion MI.
UR - http://www.scopus.com/inward/record.url?scp=85090077580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090077580&partnerID=8YFLogxK
U2 - 10.4244/EIJ-D-19-01120
DO - 10.4244/EIJ-D-19-01120
M3 - Article
C2 - 32310133
AN - SCOPUS:85090077580
SN - 1774-024X
VL - 16
SP - 380
EP - 386
JO - EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
JF - EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
IS - 5
ER -